Literature DB >> 26666171

Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum.

Wei-Hua Yuan1,2, Masuo Goto2, Kan-Yen Hsieh2,3, Bo Yuan1, Yu Zhao2, Susan L Morris-Natschke2, Kuo-Hsiung Lee2,4.   

Abstract

One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed weak activity against KB-VIN (IC50 = 11.0 ± 0.156 μM), while the known compound 3 exhibited selective cytotoxicity against MDA-MB-231 triple-negative breast cancer (TNBC) (IC50 = 5.42 ± 0.167 μM).

Entities:  

Keywords:  Metabolites; Penicillium citreonigrum; cytotoxic; eremophilane-type sesquiterpene

Mesh：

Substances：

Year:  2015        PMID： 26666171      PMCID： PMC4878012          DOI： 10.1080/10286020.2015.1115020

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  3 in total

1.  Studies in the biochemistry of micro-organisms. 86. The molecular constitution of mycophenolic acid, a metabolic product of Penicillium Brevi-compactum Dierckx. Part III. Further observations on the structural formula for mycophenolic acid.

Authors:  J H BIRKINSHAW; H RAISTRICK; D J ROSS
Journal:  Biochem J       Date:  1952-03       Impact factor: 3.857

2.  Halogenated metabolites isolated from Penicillium citreonigrum.

Authors:  Wei-Hua Yuan; Zhi-Wen Wei; Peng Dai; Hui Wu; Yan-Xia Zhao; Mei-Mei Zhang; Nan Jiang; Wei-Fa Zheng
Journal:  Chem Biodivers       Date:  2014-07       Impact factor: 2.408

3.  Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring.

Authors:  Kyoko Nakagawa-Goto; Akifumi Oda; Ernest Hamel; Emika Ohkoshi; Kuo-Hsiung Lee; Masuo Goto
Journal:  J Med Chem       Date:  2015-02-26       Impact factor: 7.446
  3 in total
  2 in total

1.  Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species.

Authors:  J Houbraken; S Kocsubé; C M Visagie; N Yilmaz; X-C Wang; M Meijer; B Kraak; V Hubka; K Bensch; R A Samson; J C Frisvad
Journal:  Stud Mycol       Date:  2020-06-27       Impact factor: 16.097

2.  Eremophilane-Type Sesquiterpenoids From the Endophytic Fungus Rhizopycnis vagum and Their Antibacterial, Cytotoxic, and Phytotoxic Activities.

Authors:  Ali Wang; Ruya Yin; Zhiyao Zhou; Gan Gu; Jungui Dai; Daowan Lai; Ligang Zhou
Journal:  Front Chem       Date:  2020-10-26       Impact factor: 5.221
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.