Larry A Fox1, Mohamed Mubasher2, Joseph I Wolfsdorf3, Bruce A Buckingham4, Anne L Peters5, William V Tamborlane6, Desmond A Schatz7, David M Maahs8, Kellee M Miller9, Roy W Beck2. 1. Nemours Children's Specialty Care, Jacksonville. 2. Jaeb Center for Health Research, Tampa. 3. Boston Children's Hospital, Boston, Massachusetts. 4. Stanford University, Palo Alto. 5. Keck School of Medicine, University of Southern California, Los Angeles, California. 6. Yale University, New Haven, Connecticut. 7. University of Florida, Gainesville, Florida. 8. Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA. 9. Jaeb Center for Health Research, Tampa. t1dstats@jaeb.org.
Abstract
BACKGROUND: The aim of the present study was to compare characteristics and diabetes management in children and adolescents with and without at least one parent with type 1 diabetes (T1D). METHODS: In all, 12 890 participants aged <18 years at enrollment in the T1D Exchange Registry were included in the present study. Statistical comparisons between those with and without parental T1D were conducted using a univariate generalized linear mixed model. RESULTS: Of the study participants, 1056 (8.2%) registrants had at least one parent with T1D. Those with parental T1D were slightly, albeit significantly, younger (6.3 vs 6.9 years; P < 0.001) and less likely to have diabetic ketoacidosis (DKA) at diagnosis (24% vs 41%; P < 0.001) than those without parental T1D. There were no differences between groups in HbA1c, use of continuous glucose monitoring or insulin pump therapy, or the development of severe hypoglycemia or DKA. In addition, there were no differences found when comparing characteristics or diabetes management in those with a mother versus those with a father with T1D. CONCLUSIONS: Children and adolescents with parental T1D tend to be diagnosed earlier. Diabetes management, glycemic control, and acute complications are similar in those with and without parental T1D.
BACKGROUND: The aim of the present study was to compare characteristics and diabetes management in children and adolescents with and without at least one parent with type 1 diabetes (T1D). METHODS: In all, 12 890 participants aged <18 years at enrollment in the T1D Exchange Registry were included in the present study. Statistical comparisons between those with and without parental T1D were conducted using a univariate generalized linear mixed model. RESULTS: Of the study participants, 1056 (8.2%) registrants had at least one parent with T1D. Those with parental T1D were slightly, albeit significantly, younger (6.3 vs 6.9 years; P < 0.001) and less likely to have diabetic ketoacidosis (DKA) at diagnosis (24% vs 41%; P < 0.001) than those without parental T1D. There were no differences between groups in HbA1c, use of continuous glucose monitoring or insulin pump therapy, or the development of severe hypoglycemia or DKA. In addition, there were no differences found when comparing characteristics or diabetes management in those with a mother versus those with a father with T1D. CONCLUSIONS:Children and adolescents with parental T1D tend to be diagnosed earlier. Diabetes management, glycemic control, and acute complications are similar in those with and without parental T1D.
Authors: Elizabeth T Jensen; Jeanette M Stafford; Sharon Saydah; Ralph B D'Agostino; Lawrence M Dolan; Jean M Lawrence; Santica Marcovina; Elizabeth J Mayer-Davis; Catherine Pihoker; Arleta Rewers; Dana Dabelea Journal: Diabetes Care Date: 2021-06-07 Impact factor: 17.152