Jing Li1, Yajie Dong1, Taixiang Wu2, Nanwei Tong3. 1. Department of Endocrinology and Metabolism, West China Hospital of Sichuan University. 2. Chinese Cochrane Center, Chinese Evidence-Based Medicine Center of International Clinical Epidemiology Network (INCLEN), Local Resource and Training Center, Chengdu, China. 3. Department of Endocrinology and Metabolism, West China Hospital of Sichuan University. buddyjun@hotmail.com.
Abstract
BACKGROUND: Differences exist between Western and Asian people with type 2 diabetes (T2D). The aim of the present systematic review was to determine whether there are differences in chronic diabetic vascular complications (CDVCs) and mortality between Western and Asian patients with T2D. METHODS: Three databases (EMBASE, MEDLINE, and Cochrane library) were searched for publications from 1966 to March 2013 describing interventional randomized control trials (RCTs) targeting to lower blood glucose levels. The RCTs included had follow-up durations of at least 4 years as an endpoint or in their initial design, analyzed effects on mortality and/or CDVCs in T2D and compared differences in mortality and/or CDVCs among patients of different ethnicities. RESULTS: Two studies, including 19 439 patients with advanced diabetes, were eligible for analysis. Patients were divided into those of Western (including Australia and New Zealand) and Asian ethnicities. The incidence of all-cause mortality, cardiovascular death, and major coronary events was significantly higher in Western than Asian patients, whereas the incidence of major cerebrovascular events, microvascular events (except for peripheral neuropathy), new or worsening nephropathy, and retinopathy was significantly lower in Western patients. There were no-between group differences in macrovascular events, including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. CONCLUSIONS: There are differences in CDVCs and mortality rates between Western and Asian patients with advanced T2D, primarily due to ethnicity-specific factors (e.g. different genetic background, lifestyle). Knowledge of these disparities may allow more effective monitoring and management of individual patients based on ethnic differences.
BACKGROUND: Differences exist between Western and Asian people with type 2 diabetes (T2D). The aim of the present systematic review was to determine whether there are differences in chronic diabetic vascular complications (CDVCs) and mortality between Western and Asian patients with T2D. METHODS: Three databases (EMBASE, MEDLINE, and Cochrane library) were searched for publications from 1966 to March 2013 describing interventional randomized control trials (RCTs) targeting to lower blood glucose levels. The RCTs included had follow-up durations of at least 4 years as an endpoint or in their initial design, analyzed effects on mortality and/or CDVCs in T2D and compared differences in mortality and/or CDVCs among patients of different ethnicities. RESULTS: Two studies, including 19 439 patients with advanced diabetes, were eligible for analysis. Patients were divided into those of Western (including Australia and New Zealand) and Asian ethnicities. The incidence of all-cause mortality, cardiovascular death, and major coronary events was significantly higher in Western than Asian patients, whereas the incidence of major cerebrovascular events, microvascular events (except for peripheral neuropathy), new or worsening nephropathy, and retinopathy was significantly lower in Western patients. There were no-between group differences in macrovascular events, including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. CONCLUSIONS: There are differences in CDVCs and mortality rates between Western and Asian patients with advanced T2D, primarily due to ethnicity-specific factors (e.g. different genetic background, lifestyle). Knowledge of these disparities may allow more effective monitoring and management of individual patients based on ethnic differences.
Authors: J H Wu; Y Q Wu; Y Wu; Z J Wang; T Wu; X Y Qin; M Y Wang; X W Wang; J T Wang; Y H Hu Journal: Beijing Da Xue Xue Bao Yi Xue Ban Date: 2022-04-18
Authors: Nina Mononen; Leo-Pekka Lyytikäinen; Ilkka Seppälä; Pashupati P Mishra; Markus Juonala; Melanie Waldenberger; Norman Klopp; Thomas Illig; Jaana Leiviskä; Britt-Marie Loo; Reijo Laaksonen; Niku Oksala; Mika Kähönen; Nina Hutri-Kähönen; Olli Raitakari; Terho Lehtimäki; Emma Raitoharju Journal: Sci Rep Date: 2019-06-20 Impact factor: 4.379
Authors: Jonathan Yap; Kamalesh Anbalakan; Wan Ting Tay; Daniel Ting; Carol Yim Cheung; Charumathi Sabanayagam; Ching-Yu Cheng; Tien-Yin Wong; Khung Keong Yeo Journal: BMJ Open Diabetes Res Care Date: 2021-07