Literature DB >> 26663349

Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery.

Xin Liu1,2, Jiajia Xiang1, Dingcheng Zhu1, Liming Jiang2, Zhuxian Zhou1, Jianbin Tang1, Xiangrui Liu1, Yongzhuo Huang3, Youqing Shen1.   

Abstract

A novel fusogenic lipidic polyplex (FLPP) vector is designed to fuse with cell membranes, mimicking viropexis, and eject the polyplex into the cytosol, where the cationic polymer is subsequently oxidized by intracellular reactive oxygen species and converts to being negatively charged, efficiently releasing the DNA. The vector delivering suicide gene achieves significantly better inhibition of tumor growth than doxorubicin.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  ROS-responsive; charge reversal polymers; fusogenic lipid vectors; gene delivery; phenylboronic acid (PBA)

Mesh：

Substances：

Year:  2015        PMID： 26663349     DOI： 10.1002/adma.201504288

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  41 in total

1.  Transferrin-Dressed Virus-like Ternary Nanoparticles with Aggregation-Induced Emission for Targeted Delivery and Rapid Cytosolic Release of siRNA.

Authors:  Tingbin Zhang; Weisheng Guo; Chunqiu Zhang; Jing Yu; Jing Xu; Shuyi Li; Jian-Hua Tian; Paul C Wang; Jin-Feng Xing; Xing-Jie Liang
Journal:  ACS Appl Mater Interfaces       Date:  2017-05-03       Impact factor: 9.229

2.  Polyamidoamine Dendrimer Grafted with an Acid-Responsive Charge-Reversal Layer for Improved Gene Delivery.

Authors:  Juan Wang; Remy C Cooper; Hu Yang
Journal:  Biomacromolecules       Date:  2020-09-08       Impact factor: 6.988

Review 3.  Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids.

Authors:  Minjie Sun; Kaikai Wang; David Oupický
Journal:  Adv Healthc Mater       Date:  2017-12-11       Impact factor: 9.933

4.  Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery.

Authors:  Jinqiang Wang; Yanqi Ye; Jicheng Yu; Anna R Kahkoska; Xudong Zhang; Chao Wang; Wujin Sun; Ria D Corder; Zhaowei Chen; Saad A Khan; John B Buse; Zhen Gu
Journal:  ACS Nano       Date:  2018-02-19       Impact factor: 15.881

5.  Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma.

Authors:  Chenxi Qu; Jizhao Li; Yejuan Zhou; Shudi Yang; Weiliang Chen; Fang Li; Bengang You; Yang Liu; Xuenong Zhang
Journal:  AAPS J       Date:  2018-02-23       Impact factor: 4.009

6.  Bioresponsive Microneedles with a Sheath Structure for H2 O2 and pH Cascade-Triggered Insulin Delivery.

Authors:  Yuqi Zhang; Jinqiang Wang; Jicheng Yu; Di Wen; Anna R Kahkoska; Yue Lu; Xudong Zhang; John B Buse; Zhen Gu
Journal:  Small       Date:  2018-02-26       Impact factor: 13.281

7.  Fabrication Of Dual pH/redox-Responsive Lipid-Polymer Hybrid Nanoparticles For Anticancer Drug Delivery And Controlled Release.

Authors:  Wanfu Men; Peiyao Zhu; Siyuan Dong; Wenke Liu; Kun Zhou; Yu Bai; Xiangli Liu; Shulei Gong; Can Yang Zhang; Shuguang Zhang
Journal:  Int J Nanomedicine       Date:  2019-10-03

8.  H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery.

Authors:  Xiuli Hu; Jicheng Yu; Chenggen Qian; Yue Lu; Anna R Kahkoska; Zhigang Xie; Xiabin Jing; John B Buse; Zhen Gu
Journal:  ACS Nano       Date:  2017-01-04       Impact factor: 15.881

9.  Photodynamic-Chemodynamic Cascade Reactions for Efficient Drug Delivery and Enhanced Combination Therapy.

Authors:  Sheng Wang; Guocan Yu; Weijing Yang; Zhantong Wang; Orit Jacobson; Rui Tian; Hongzhang Deng; Lisen Lin; Xiaoyuan Chen
Journal:  Adv Sci (Weinh)       Date:  2021-04-08       Impact factor: 16.806

Review 10.  Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems.

Authors:  Fengxiang Gao; Zhengrong Xiong
Journal:  Front Chem       Date:  2021-04-23       Impact factor: 5.221
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