Literature DB >> 26662983

A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics.

Gaetano Santulli1.   

Abstract

MicroRNAs (miRs) are important regulators of gene expression in numerous biological processes. Their maturation process is herein described, including the most updated insights from the current literature. Circa 2000 miR sequences have been identified in the human genome, with over 50,000 miR-target interactions, including enzymes involved in epigenetic modulation of gene expression. Moreover, some "pieces of RNA" previously annotated as noncoding have been recently found to encode micropeptides that carry out critical mechanistic functions in the cell. Advanced techniques now available will certainly allow a precise scanning of the genome looking for micropeptides hidden within the "noncoding" RNA.

Entities:  

Keywords:  Dicer; Drosha; EpimiR; Exportin; Humanin; METTL3; MOTS-c; Micropeptides; Micropeptidome; Micropeptidomics; Mitochondria; Myogenin; ORF; Pharmacogenomics; Precision medicine; RISC; SERCA; TargetScan; Transcriptome; miRBase; miRNA; miRWalk

Mesh：

Substances：

Year:  2015        PMID： 26662983      PMCID： PMC4871246          DOI： 10.1007/978-3-319-22380-3_1

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  119 in total

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Journal:  Nature       Date:  2015-03-25       Impact factor: 49.962

3.  Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.

Authors:  Liang Chu; Mack Y Su; Leonard B Maggi; Lan Lu; Chelsea Mullins; Seth Crosby; Gaofeng Huang; Wee Joo Chng; Ravi Vij; Michael H Tomasson
Journal:  J Clin Invest       Date:  2012-07-02       Impact factor: 14.808

4.  Structural features of Argonaute-GW182 protein interactions.

Authors:  Janina Pfaff; Janosch Hennig; Franz Herzog; Ruedi Aebersold; Michael Sattler; Dierk Niessing; Gunter Meister
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

5.  Humanin peptide suppresses apoptosis by interfering with Bax activation.

Authors:  Bin Guo; Dayong Zhai; Edelmira Cabezas; Kate Welsh; Shahrzad Nouraini; Arnold C Satterthwait; John C Reed
Journal:  Nature       Date:  2003-05-04       Impact factor: 49.962

6.  Mammalian microRNAs predominantly act to decrease target mRNA levels.

Authors:  Huili Guo; Nicholas T Ingolia; Jonathan S Weissman; David P Bartel
Journal:  Nature       Date:  2010-08-12       Impact factor: 49.962

7.  The transcriptional landscape of the mammalian genome.

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Journal:  Science       Date:  2005-09-02       Impact factor: 47.728

8.  The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localization.

Authors:  Ryan J Taft; Peter G Hawkins; John S Mattick; Kevin V Morris
Journal:  Epigenetics Chromatin       Date:  2011-08-03       Impact factor: 4.954

9.  Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.

Authors:  Zhenji Gan; John Rumsey; Bethany C Hazen; Ling Lai; Teresa C Leone; Rick B Vega; Hui Xie; Kevin E Conley; Johan Auwerx; Steven R Smith; Eric N Olson; Anastasia Kralli; Daniel P Kelly
Journal:  J Clin Invest       Date:  2013-05-08       Impact factor: 14.808

10.  Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis.

Authors:  Matteo Fassan; Luigi Dall'Olmo; Marco Galasso; Chiara Braconi; Marco Pizzi; Stefano Realdon; Stefano Volinia; Nicola Valeri; Pierluigi Gasparini; Raffaele Baffa; Rhonda F Souza; Caterina Vicentini; Edoardo D'Angelo; Jan Bornschein; Gerard J Nuovo; Giovanni Zaninotto; Carlo M Croce; Massimo Rugge
Journal:  Oncotarget       Date:  2014-08-30
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  1 in total

Review 1.  MicroRNAs and Endothelial (Dys) Function.

Authors:  Gaetano Santulli
Journal:  J Cell Physiol       Date:  2015-12-30       Impact factor: 6.384
  1 in total

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