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Literature DB >> 26662812

Synthesis of a Cationic BODIPY-Containing Conjugated Polymer for Detection of DNA and Cellular Imaging.

Lingyun Wang¹, Guipo Fang², Derong Cao².

Abstract

A water-soluble cationic conjugated polyelectrolyte (P1) containing fluorene, BODIPY and diacetylene moieties was synthesized and characterized. P1 showed two main absorption bands with maxima at 360 and 574 nm as well as fluorescence maxima at 648 nm due to the incorporation of BODIPY into the polymer backbone. Addition of CT DNA can quench the emission of P1 because of the formation of a P1/CT DNA complex, which was demonstrated by UV-vis spectra and dynamic light scattering (DLS) analyses. Cellular imaging results indicated P1 could be utilized as cellular imaging of HeLa cells, where red fluorescence was observed in the partial cytoplasm. Moreover, CCK-8 assay showed P1 had a low cytotoxicity.

Entities: Chemical Disease

Keywords: BODIPY; Cellular imaging; Conjugated polyelectrolytes; DNA

Mesh：

Substances：

Year: 2015 PMID： 26662812 DOI： 10.1007/s10895-015-1729-4

Source DB: PubMed Journal: J Fluoresc ISSN： 1053-0509 Impact factor: 2.217

19 in total

Review 1. Water-soluble conjugated polymers for imaging, diagnosis, and therapy.

Authors: Chunlei Zhu; Libing Liu; Qiong Yang; Fengting Lv; Shu Wang
Journal: Chem Rev Date: 2012-06-06 Impact factor: 60.622

2. Chemical sensors based on amplifying fluorescent conjugated polymers.

Authors: Samuel W Thomas; Guy D Joly; Timothy M Swager
Journal: Chem Rev Date: 2007-03-27 Impact factor: 60.622

3. Direct energy transfer from conjugated polymer to DNA intercalated dye: label-free fluorescent DNA detection.

Authors: Bing Wang; Qiong Yang; Libing Liu; Shu Wang
Journal: Colloids Surf B Biointerfaces Date: 2010-10-20 Impact factor: 5.268

4. The chemistry of fluorescent bodipy dyes: versatility unsurpassed.

Authors: Gilles Ulrich; Raymond Ziessel; Anthony Harriman
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

5. Highly sensitive and selective detection of mercury ions by using oligonucleotides, DNA intercalators, and conjugated polymers.

Authors: Xinsheng Ren; Qing-Hua Xu
Journal: Langmuir Date: 2009-01-06 Impact factor: 3.882

6. Label-free DNA sequence detection with enhanced sensitivity and selectivity using cationic conjugated polymers and PicoGreen.

Authors: Xinsheng Ren; Qing-Hua Xu
Journal: Langmuir Date: 2009-01-06 Impact factor: 3.882

Synthesis of a Cationic BODIPY-Containing Conjugated Polymer for Detection of DNA and Cellular Imaging.

Review 1. Water-soluble conjugated polymers for imaging, diagnosis, and therapy.

2. Chemical sensors based on amplifying fluorescent conjugated polymers.

3. Direct energy transfer from conjugated polymer to DNA intercalated dye: label-free fluorescent DNA detection.

4. The chemistry of fluorescent bodipy dyes: versatility unsurpassed.

5. Highly sensitive and selective detection of mercury ions by using oligonucleotides, DNA intercalators, and conjugated polymers.

6. Label-free DNA sequence detection with enhanced sensitivity and selectivity using cationic conjugated polymers and PicoGreen.

7. Colorimetric and fluorometric detection of nucleic acids using cationic polythiophene derivatives.

8. BODIPY dyes and their derivatives: syntheses and spectroscopic properties.

9. Brilliant BODIPY-fluorene Copolymers With Dispersed Absorption and Emission Maxima.

Review 10. Optical detection of DNA and proteins with cationic polythiophenes.

Review 1. Recent Progress in Near-Infrared Organic Electroluminescent Materials.