Anita Feller1, Martin Fehr2, Andrea Bordoni3, Christine Bouchardy4, Harald Frick5, Mohsen Mousavi6, Annik Steiner7, Volker Arndt8, Kerri M Clough-Gorr9. 1. National Institute for Cancer Epidemiology and Registration (NICER), Zürich, Switzerland; Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland. 2. Kantonsspital St. Gallen, Department Oncology and Haematology, St. Gallen, Switzerland. 3. Ticino Cancer Registry, Institute of Pathology, Locarno, Switzerland. 4. Geneva Cancer Registry, Institute of Global Health, University of Geneva, Switzerland. 5. Cancer Registry St Gallen-Appenzell, Cancer League St. Gallen-Appenzell, St. Gallen, Switzerland. 6. Cancer Registry of Basel-Stadt and Basel-Landschaft, Gesundheitsdepartement des Kantons Basel-Stadt, Bereich Gesundheitsdienste, Abteilung Projekte und Services, Basel, Switzerland. 7. SAKK Coordinating Centre, Bern, Switzerland. 8. National Institute for Cancer Epidemiology and Registration (NICER), Zürich, Switzerland. 9. Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland.
Abstract
QUESTION UNDER STUDY/PRINCIPLES: This study aimed to evaluate trends in the incidence of oesophageal and gastric cancer by anatomical location and histology using nationally representative Swiss data. METHODS: We included all oesophageal and gastric cancers recorded in 10 Swiss population-based cancer registries 1982-2011. We calculated age-standardised incidence rates (ASIRs) per 100 000 person-years (PY) (European standard) for both cancer sites stratified by sex, language region (German, French-Italian), morphology and anatomical location. To assess time trends, we estimated annual percentage changes (APCs) with 95% confidence intervals (95% CIs). RESULTS: ASIR of oesophageal adenocarcinoma increased in both sexes and language regions (p <0.001). The steepest increase occurred in males of the German-speaking region (APC 6.8%, 95% CI 5.8-7.8) with ASIRs of 0.8 per 100,000 PY in 1982-1987 and 3.9 per 100.000 PY in 2007-2011. Incidence of oesophageal squamous cell carcinoma decreased significantly in males of both language regions by around -1.5% per year. In contrast, a slight but significant increase (APC 1.4%, 95% CI 0.3-2.4]) of oesophageal squamous cell carcinoma was observed in females of the German-speaking region. We observed stable rates for cancer of the gastric cardia. The incidence of noncardia gastric cancer decreased substantially in both sexes and language regions (p <0.001). CONCLUSION: In Switzerland, the incidence of oesophageal adenocarcinoma has risen whereas incidence of noncardia gastric cancer has decreased substantially as observed in other developed countries.
QUESTION UNDER STUDY/PRINCIPLES: This study aimed to evaluate trends in the incidence of oesophageal and gastric cancer by anatomical location and histology using nationally representative Swiss data. METHODS: We included all oesophageal and gastric cancers recorded in 10 Swiss population-based cancer registries 1982-2011. We calculated age-standardised incidence rates (ASIRs) per 100 000 person-years (PY) (European standard) for both cancer sites stratified by sex, language region (German, French-Italian), morphology and anatomical location. To assess time trends, we estimated annual percentage changes (APCs) with 95% confidence intervals (95% CIs). RESULTS: ASIR of oesophageal adenocarcinoma increased in both sexes and language regions (p <0.001). The steepest increase occurred in males of the German-speaking region (APC 6.8%, 95% CI 5.8-7.8) with ASIRs of 0.8 per 100,000 PY in 1982-1987 and 3.9 per 100.000 PY in 2007-2011. Incidence of oesophageal squamous cell carcinoma decreased significantly in males of both language regions by around -1.5% per year. In contrast, a slight but significant increase (APC 1.4%, 95% CI 0.3-2.4]) of oesophageal squamous cell carcinoma was observed in females of the German-speaking region. We observed stable rates for cancer of the gastric cardia. The incidence of noncardia gastric cancer decreased substantially in both sexes and language regions (p <0.001). CONCLUSION: In Switzerland, the incidence of oesophageal adenocarcinoma has risen whereas incidence of noncardia gastric cancer has decreased substantially as observed in other developed countries.
Authors: Dan Cameniţă; Alin Dragoş Demetrian; Răzvan Mihail Pleşea; Manuela Ioana Tănasie-Vasile; Victor Dan Eugen Strâmbu; Valentin Titus Grigorean; Elena Ioniţă; Iancu Emil Pleşea; Augustin Marian Marincaş Journal: Rom J Morphol Embryol Date: 2020 Apr-Jun Impact factor: 1.033