Literature DB >> 2666171

The interaction of beta-N-methylamino-L-alanine with bicarbonate: an 1H-NMR study.

P B Nunn1, P O'Brien.   

Abstract

The mode of action of the neurotoxic, non-protein amino acid beta-N-methylamino-L-alanine (L-BMAA) is unknown. We have shown, using 1H-NMR spectroscopy, that L-BMAA forms a stable adduct with bicarbonate (probably a carbamate). The properties of this adduct may explain the observation that L-BMAA and N-methyl-D-aspartic acid appear to act at the same central nervous system receptors.

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Year:  1989        PMID： 2666171     DOI： 10.1016/0014-5793(89)81423-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

1.  Olfactory recognition of a trimethylsilylcarbamate as a carboxylic acid.

Authors:  D Jewett
Journal:  Naturwissenschaften       Date:  1992-11

Review 2.  Neuropathological Mechanisms of β-N-Methylamino-L-Alanine (BMAA) with a Focus on Iron Overload and Ferroptosis.

Authors:  Hamed Kazemi Shariat Panahi; Mona Dehhaghi; Benjamin Heng; Darius J R Lane; Ashley I Bush; Gilles J Guillemin; Vanessa X Tan
Journal:  Neurotox Res       Date:  2022-01-13       Impact factor: 3.911

3.  Prominent human health impacts from several marine microbes: history, ecology, and public health implications.

Authors:  P K Bienfang; S V Defelice; E A Laws; L E Brand; R R Bidigare; S Christensen; H Trapido-Rosenthal; T K Hemscheidt; D J McGillicuddy; D M Anderson; H M Solo-Gabriele; A B Boehm; L C Backer
Journal:  Int J Microbiol       Date:  2010-10-11

4.  Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.

Authors:  Hong Z Yin; Stephen Yu; Cheng-I Hsu; Joe Liu; Allan Acab; Richard Wu; Anna Tao; Benjamin J Chiang; John H Weiss
Journal:  Exp Neurol       Date:  2014-06-08       Impact factor: 5.330

5.  Chemistry and Chemical Equilibrium Dynamics of BMAA and Its Carbamate Adducts.

Authors:  Pedro Diaz-Parga; Joy J Goto; V V Krishnan
Journal:  Neurotox Res       Date:  2017-09-18       Impact factor: 3.978

6.  A Single Laboratory Validation for the Analysis of Underivatized β-N-Methylamino-L-Alanine (BMAA).

Authors:  Fiona J M Tymm; Stephanie L Bishop; Susan J Murch
Journal:  Neurotox Res       Date:  2019-12-11       Impact factor: 3.911

7.  On the Differential Roles of Mg2+, Zn2+, and Cu2+ in the Equilibrium of β-N-Methyl-Amino-L-Alanine (BMAA) and its Carbamates.

Authors:  Pedro Diaz-Parga; Joy J Goto; V V Krishnan
Journal:  Neurotox Res       Date:  2020-01-18       Impact factor: 3.911

8.  BMAA inhibits nitrogen fixation in the cyanobacterium Nostoc sp. PCC 7120.

Authors:  Lotta Berntzon; Sven Erasmie; Narin Celepli; Johan Eriksson; Ulla Rasmussen; Birgitta Bergman
Journal:  Mar Drugs       Date:  2013-08-21       Impact factor: 5.118

9.  Maternal transfer of the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) via milk to suckling offspring.

Authors:  Marie Andersson; Oskar Karlsson; Ulrika Bergström; Eva B Brittebo; Ingvar Brandt
Journal:  PLoS One       Date:  2013-10-23       Impact factor: 3.240

10.  Equilibrium Dynamics of β-N-Methylamino-L-Alanine (BMAA) and Its Carbamate Adducts at Physiological Conditions.

Authors:  David Zimmerman; Joy J Goto; Viswanathan V Krishnan
Journal:  PLoS One       Date:  2016-08-11       Impact factor: 3.240
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