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Literature DB >> 26661526

Novel Functions of Renin Precursors in Homeostasis and Disease.

R Ariel Gomez¹, Maria Luisa S Sequeira-Lopez¹.

Abstract

Renin progenitors appear early and are found in multiple tissues throughout the embryo. Besides their well known role in blood pressure and fluid homeostasis, renin progenitors participate in tissue morphogenesis, repair, and regeneration, and may integrate immune and endocrine responses. In the bone marrow, renin cells offer clues to understand normal and neoplastic hematopoiesis. ©2016 Int. Union Physiol. Sci./Am. Physiol. Soc.

Entities: Disease Gene

Mesh：

Substances：
Renin

Year: 2016 PMID： 26661526 PMCID： PMC4698453 DOI： 10.1152/physiol.00039.2015

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

55 in total

1. Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.

Authors: Ruth M Castellanos Rivera; Maria C Monteagudo; Ellen S Pentz; Sean T Glenn; Kenneth W Gross; Oscar Carretero; Maria Luisa S Sequeira-Lopez; R Ariel Gomez
Journal: Physiol Genomics Date: 2011-07-12 Impact factor: 3.107

2. Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme.

Authors: K F Hilgers; V Reddi; J H Krege; O Smithies; R A Gomez
Journal: Hypertension Date: 1997-01 Impact factor: 10.190

3. Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling.

Authors: Eugene E Lin; Ellen S Pentz; Maria Luisa S Sequeira-Lopez; R Ariel Gomez
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2015-07-15 Impact factor: 3.619

4. Two microRNAs, miR-330 and miR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype.

Authors: Silvia Medrano; Maria C Monteagudo; Maria Luisa S Sequeira-Lopez; Ellen S Pentz; R Ariel Gomez
Journal: Am J Physiol Renal Physiol Date: 2011-10-12

5. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

Authors: C R Esther; T E Howard; E M Marino; J M Goddard; M R Capecchi; K E Bernstein
Journal: Lab Invest Date: 1996-05 Impact factor: 5.662

6. Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype.

Authors: Ellen Steward Pentz; Maria Alejandra Moyano; Barbara A Thornhill; Maria Luisa S Sequeira Lopez; R Ariel Gomez
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2003-10-16 Impact factor: 3.619

7. Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease.

Authors: Jeffrey W Pippin; Matthew A Sparks; Sean T Glenn; Sandra Buitrago; Thomas M Coffman; Jeremy S Duffield; Kenneth W Gross; Stuart J Shankland
Journal: Am J Pathol Date: 2013-06-14 Impact factor: 4.307

8. Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1).

Authors: H A Thompson; J M Burson; J A Lang; K W Gross; C D Sigmund
Journal: Endocrinology Date: 1995-07 Impact factor: 4.736

9. The GUDMAP database--an online resource for genitourinary research.

Authors: Simon D Harding; Chris Armit; Jane Armstrong; Jane Brennan; Ying Cheng; Bernard Haggarty; Derek Houghton; Sue Lloyd-MacGilp; Xingjun Pi; Yogmatee Roochun; Mehran Sharghi; Christopher Tindal; Andrew P McMahon; Brian Gottesman; Melissa H Little; Kylie Georgas; Bruce J Aronow; S Steven Potter; Eric W Brunskill; E Michelle Southard-Smith; Cathy Mendelsohn; Richard A Baldock; Jamie A Davies; Duncan Davidson
Journal: Development Date: 2011-07 Impact factor: 6.868

10. Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia.

Authors: Brian C Belyea; Fang Xu; Ellen S Pentz; Silvia Medrano; Minghong Li; Yan Hu; Stephen Turner; Robin Legallo; Craig A Jones; Joseph D Tario; Ping Liang; Kenneth W Gross; Maria Luisa S Sequeira-Lopez; R Ariel Gomez
Journal: Nat Commun Date: 2014 Impact factor: 14.919

17 in total

1. Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage.

Authors: Peter Lachmann; Linda Hickmann; Anne Steglich; Moath Al-Mekhlafi; Michael Gerlach; Niels Jetschin; Steffen Jahn; Brigitte Hamann; Monika Wnuk; Kirsten Madsen; Valentin Djonov; Min Chen; Lee S Weinstein; Bernd Hohenstein; Christian P M Hugo; Vladimir T Todorov
Journal: J Am Soc Nephrol Date: 2017-08-03 Impact factor: 10.121

2. How can juxtaglomerular renin-producing cells support the integrity of glomerular endothelial cells?

Authors: Armin Kurtz
Journal: Pflugers Arch Date: 2019-08-08 Impact factor: 3.657

3. Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis.

Authors: Maria Florencia Martinez; Silvia Medrano; Evan A Brown; Turan Tufan; Stephen Shang; Nadia Bertoncello; Omar Guessoum; Mazhar Adli; Brian C Belyea; Maria Luisa S Sequeira-Lopez; R Ariel Gomez
Journal: J Clin Invest Date: 2018-10-02 Impact factor: 14.808

Novel Functions of Renin Precursors in Homeostasis and Disease.

1. Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.

2. Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme.

3. Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling.

4. Two microRNAs, miR-330 and miR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype.

5. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

6. Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype.

7. Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease.

8. Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1).

9. The GUDMAP database--an online resource for genitourinary research.

10. Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia.

1. Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage.

2. How can juxtaglomerular renin-producing cells support the integrity of glomerular endothelial cells?

3. Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis.

4. Chronic Stimulation of Renin Cells Leads to Vascular Pathology.

5. Ontogeny of renin gene expression in the chicken, Gallus gallus.

Review 6. Fate of Renin Cells During Development and Disease.

Review 7. Development of the renal vasculature.

Review 8. Plasticity of Renin Cells in the Kidney Vasculature.

Review 9. Renin cells in homeostasis, regeneration and immune defence mechanisms.

Review 10. Renin Cells, the Kidney, and Hypertension.