Literature DB >> 26661197

Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide.

Seth Truran1, Volkmar Weissig2, Jillian Madine3, Hannah A Davies3, Diana Guzman-Villanueva2, Daniel A Franco1, Nina Karamanova1, Camelia Burciu1, Geidy Serrano4, Thomas G Beach4, Raymond Q Migrino5.   

Abstract

We tested whether nanoliposomes containing phosphatidylcholine, cholesterol and phosphatidic acid (NLPA) prevent β-amyloid 1-42 (Aβ42) fibrillation and Aβ42-induced human arteriole endothelial dysfunction. NLPA abolished Aβ42 fibril formation (thioflavin-T fluorescence/electron microscopy). In ex-vivo human adipose and leptomeningeal arterioles, Aβ42 impaired dilator response to acetylcholine that was reversed by NLPA; this protection was abolished by L-NG-nitroarginine methyl ester. Aβ42 reduced human umbilical vein endothelial cell NO production that was restored by NLPA. Nanoliposomes prevented Aβ42 amyloid formation, reversed Aβ42-induced human microvascular endothelial dysfunction and may be useful in Alzheimer's disease.
© The Author(s) 2015.

Entities:  

Keywords:  Alzheimer’s disease; Amyloid; endothelial function; liposome; microvasculature

Mesh：

Substances：

Year:  2015        PMID： 26661197      PMCID： PMC4759678          DOI： 10.1177/0271678X15610134

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  20 in total

Review 1.  eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity.

Authors:  Ruslan Rafikov; Fabio V Fonseca; Sanjiv Kumar; Daniel Pardo; Charles Darragh; Shawn Elms; David Fulton; Stephen M Black
Journal:  J Endocrinol       Date:  2011-06-03       Impact factor: 4.286

2.  Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide.

Authors:  Francesca Re; Ilaria Cambianica; Silvia Sesana; Elisa Salvati; Alfredo Cagnotto; Mario Salmona; Pierre-Olivier Couraud; S Moein Moghimi; Massimo Masserini; Giulio Sancini
Journal:  J Biotechnol       Date:  2011-07-06       Impact factor: 3.307

3.  Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins.

Authors:  Raymond Q Migrino; Seth Truran; David D Gutterman; Daniel A Franco; Megan Bright; Brittany Schlundt; Mitchell Timmons; Angelica Motta; Shane A Phillips; Parameswaran Hari
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-09-30       Impact factor: 4.733

4.  Palmitoylethanolamide Regulates Production of Pro-Angiogenic Mediators in a Model of β Amyloid-Induced Astrogliosis In Vitro.

Authors:  Mariateresa Cipriano; Giueseppe Esposito; Luana Negro; Elena Capoccia; Giovanni Sarnelli; Caterina Scuderi; Daniele De Filippis; Luca Steardo; Teresa Iuvone
Journal:  CNS Neurol Disord Drug Targets       Date:  2015       Impact factor: 4.388

Review 5.  Alzheimer disease as a vascular disorder: nosological evidence.

Authors:  J C de la Torre
Journal:  Stroke       Date:  2002-04       Impact factor: 7.914

6.  Systemic and microvascular oxidative stress induced by light chain amyloidosis.

Authors:  Raymond Q Migrino; Parameswaran Hari; David D Gutterman; Megan Bright; Seth Truran; Brittany Schlundt; Shane A Phillips
Journal:  Int J Cardiol       Date:  2009-05-15       Impact factor: 4.164

7.  Nanoliposomes protect against AL amyloid light chain protein-induced endothelial injury.

Authors:  Seth Truran; Volkmar Weissig; Marina Ramirez-Alvarado; Daniel A Franco; Camelia Burciu; Joseph Georges; Shishir Murarka; Winter A Okoth; Sara Schwab; Parameswaran Hari; Raymond Q Migrino
Journal:  J Liposome Res       Date:  2013-11-15       Impact factor: 3.648

8.  Protective role of clusterin in preserving endothelial function in AL amyloidosis.

Authors:  Daniel A Franco; Seth Truran; Camelia Burciu; David D Gutterman; Anthony Maltagliati; Volkmar Weissig; Parameswaran Hari; Raymond Q Migrino
Journal:  Atherosclerosis       Date:  2012-09-01       Impact factor: 5.162

9.  Adipose and leptomeningeal arteriole endothelial dysfunction induced by β-amyloid peptide: a practical human model to study Alzheimer's disease vasculopathy.

Authors:  Seth Truran; Daniel A Franco; Alex E Roher; Thomas G Beach; Camelia Burciu; Geidy Serrano; Chera L Maarouf; Sara Schwab; Jenna Anderson; Joseph Georges; Peter Reaven; Raymond Q Migrino
Journal:  J Neurosci Methods       Date:  2014-07-05       Impact factor: 2.390

10.  Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease.

Authors:  Markus Morawski; Stephan Schilling; Moritz Kreuzberger; Alexander Waniek; Carsten Jäger; Birgit Koch; Holger Cynis; Astrid Kehlen; Thomas Arendt; Maike Hartlage-Rübsamen; Hans-Ulrich Demuth; Steffen Roßner
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472
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  7 in total

1.  Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia.

Authors:  Raymond Q Migrino; Seth Truran; Nina Karamanova; Geidy E Serrano; Calvin Madrigal; Hannah A Davies; Jillian Madine; Peter Reaven; Thomas G Beach
Journal:  Am J Physiol Heart Circ Physiol       Date:  2018-05-18       Impact factor: 4.733

2.  Monosialoganglioside-Containing Nanoliposomes Restore Endothelial Function Impaired by AL Amyloidosis Light Chain Proteins.

Authors:  Daniel A Franco; Seth Truran; Volkmar Weissig; Diana Guzman-Villanueva; Nina Karamanova; Subhadip Senapati; Camelia Burciu; Marina Ramirez-Alvarado; Luis M Blancas-Mejia; Stuart Lindsay; Parameswaran Hari; Raymond Q Migrino
Journal:  J Am Heart Assoc       Date:  2016-06-13       Impact factor: 5.501

3.  PEGylated-nanoliposomal clusterin for amyloidogenic light chain-induced endothelial dysfunction.

Authors:  Diana Guzman-Villanueva; Raymond Q Migrino; Seth Truran; Nina Karamanova; Daniel A Franco; Camelia Burciu; Subhadip Senapati; Dobrin Nedelkov; Parameswaran Hari; Volkmar Weissig
Journal:  J Liposome Res       Date:  2017-02-10       Impact factor: 3.648

4.  High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture.

Authors:  Jérôme Robert; Emily B Button; Sophie Stukas; Guilaine K Boyce; Ebrima Gibbs; Catherine M Cowan; Megan Gilmour; Wai Hang Cheng; Sonja K Soo; Brian Yuen; Arvin Bahrabadi; Kevin Kang; Iva Kulic; Gordon Francis; Neil Cashman; Cheryl L Wellington
Journal:  Mol Neurodegener       Date:  2017-08-22       Impact factor: 14.195

5.  Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes.

Authors:  Nina Karamanova; Seth Truran; Geidy E Serrano; Thomas G Beach; Jillian Madine; Volkmar Weissig; Hannah A Davies; Jaimeson Veldhuizen; Mehdi Nikkhah; Michael Hansen; Weiyang Zhang; Karen D'Souza; Daniel A Franco; Raymond Q Migrino
Journal:  J Am Heart Assoc       Date:  2020-01-13       Impact factor: 5.501

6.  Amyloidogenic medin induces endothelial dysfunction and vascular inflammation through the receptor for advanced glycation endproducts.

Authors:  Raymond Q Migrino; Hannah A Davies; Seth Truran; Nina Karamanova; Daniel A Franco; Thomas G Beach; Geidy E Serrano; Danh Truong; Mehdi Nikkhah; Jillian Madine
Journal:  Cardiovasc Res       Date:  2017-09-01       Impact factor: 10.787

7.  Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels.

Authors:  Jerome Robert; Emily B Button; Brian Yuen; Megan Gilmour; Kevin Kang; Arvin Bahrabadi; Sophie Stukas; Wenchen Zhao; Iva Kulic; Cheryl L Wellington
Journal:  Elife       Date:  2017-10-10       Impact factor: 8.140
  7 in total

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