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Literature DB >> 26661115

Genetic factors affect the etiology, clinical characteristics and outcome of autoimmune hepatitis.

Abstract

Autoimmune hepatitis (AIH) is characterized by chronic inflammation of the liver, hypergammaglobulinemia, the presence of serum autoantibodies, histologic evidence of interface hepatitis, and a favorable response to immunosuppressive treatment. Although the etiology of AIH remains undefined, human leukocyte antigen (HLA) class II alleles have been associated with disease onset for decades. AIH resistance and severity are presumably linked to HLA alleles as well. Individuals in different geographic regions of the world may have varying susceptibility alleles that reflect indigenous triggering antigens. In this review, we describe the influence of HLA alleles and gene polymorphisms on AIH, along with the results of genome-wide association studies on this disease.

Entities: Disease Species

Keywords: Autoimmune hepatitis; HLA; Primary biliary cirrhosis

Mesh：

Substances：
HLA Antigens

Year: 2015 PMID： 26661115 DOI： 10.1007/s12328-015-0620-9

Source DB: PubMed Journal: Clin J Gastroenterol ISSN： 1865-7265

49 in total

1. Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease.

Authors: Yun Ma; Manabu Okamoto; Mark G Thomas; Dimitrios P Bogdanos; Agnel R Lopes; Bernard Portmann; James Underhill; Ralf Dürr; Giorgina Mieli-Vergani; Diego Vergani
Journal: Hepatology Date: 2002-03 Impact factor: 17.425

2. Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium.

Authors:
Journal: Nature Date: 1999-10-28 Impact factor: 49.962

3. A possible association between basic amino acids of position 13 of DRB1 chains and autoimmune hepatitis.

Authors: M Ota; T Seki; K Kiyosawa; S Furuta; K Hino; T Kondo; H Fukushima; K Tsuji; H Inoko
Journal: Immunogenetics Date: 1992 Impact factor: 2.846

4. Diagnosis and management of autoimmune hepatitis.

Authors: Michael P Manns; Albert J Czaja; James D Gorham; Edward L Krawitt; Giorgina Mieli-Vergani; Diego Vergani; John M Vierling
Journal: Hepatology Date: 2010-06 Impact factor: 17.425

5. Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.

Authors: Ynto S de Boer; Nicole M F van Gerven; Antonie Zwiers; Bart J Verwer; Bart van Hoek; Karel J van Erpecum; Ulrich Beuers; Henk R van Buuren; Joost P H Drenth; Jannie W den Ouden; Robert C Verdonk; Ger H Koek; Johannes T Brouwer; Maureen M J Guichelaar; Jan M Vrolijk; Georg Kraal; Chris J J Mulder; Carin M J van Nieuwkerk; Janett Fischer; Thomas Berg; Felix Stickel; Christoph Sarrazin; Christoph Schramm; Ansgar W Lohse; Christina Weiler-Normann; Markus M Lerch; Matthias Nauck; Henry Völzke; Georg Homuth; Elisabeth Bloemena; Hein W Verspaget; Vinod Kumar; Alexandra Zhernakova; Cisca Wijmenga; Lude Franke; Gerd Bouma
Journal: Gastroenterology Date: 2014-04-23 Impact factor: 22.682

6. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

Authors: Espen Melum; Andre Franke; Christoph Schramm; Tobias J Weismüller; Daniel Nils Gotthardt; Felix A Offner; Brian D Juran; Jon K Laerdahl; Verena Labi; Einar Björnsson; Rinse K Weersma; Liesbet Henckaerts; Andreas Teufel; Christian Rust; Eva Ellinghaus; Tobias Balschun; Kirsten Muri Boberg; David Ellinghaus; Annika Bergquist; Peter Sauer; Euijung Ryu; Johannes Roksund Hov; Jochen Wedemeyer; Björn Lindkvist; Michael Wittig; Robert J Porte; Kristian Holm; Christian Gieger; H-Erich Wichmann; Pieter Stokkers; Cyriel Y Ponsioen; Heiko Runz; Adolf Stiehl; Cisca Wijmenga; Martina Sterneck; Severine Vermeire; Ulrich Beuers; Andreas Villunger; Erik Schrumpf; Konstantinos N Lazaridis; Michael P Manns; Stefan Schreiber; Tom H Karlsen
Journal: Nat Genet Date: 2010-12-12 Impact factor: 38.330

7. A functional Fas promoter polymorphism is associated with a severe phenotype in type 1 autoimmune hepatitis characterized by early development of cirrhosis.

Authors: K Agarwal; A J Czaja; P T Donaldson
Journal: Tissue Antigens Date: 2007-03

8. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

Authors: Gideon M Hirschfield; Xiangdong Liu; Chun Xu; Yue Lu; Gang Xie; Yan Lu; Xiangjun Gu; Erin J Walker; Kaiyan Jing; Brian D Juran; Andrew L Mason; Robert P Myers; Kevork M Peltekian; Cameron N Ghent; Catalina Coltescu; Elizabeth J Atkinson; E Jenny Heathcote; Konstantinos N Lazaridis; Christopher I Amos; Katherine A Siminovitch
Journal: N Engl J Med Date: 2009-05-20 Impact factor: 91.245

Genetic factors affect the etiology, clinical characteristics and outcome of autoimmune hepatitis.

1. Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease.

2. Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium.

3. A possible association between basic amino acids of position 13 of DRB1 chains and autoimmune hepatitis.

4. Diagnosis and management of autoimmune hepatitis.

5. Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.

6. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

7. A functional Fas promoter polymorphism is associated with a severe phenotype in type 1 autoimmune hepatitis characterized by early development of cirrhosis.

8. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

9. Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese.

10. Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis.

Review 1. Immunology of hepatic diseases during pregnancy.

Review 2. Genetics and epigenetics in the pathogenesis of primary biliary cholangitis.

Review 3. Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis.

Review 4. Autoimmune hepatitis: current challenges and future prospects.

Review 5. The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective.