| Literature DB >> 26659874 |
Da-Hong Li1,2,3, Chen-Xi Li1,3, Cui-Cui Jia1,3, Ya-Ting Sun1,3, Chun-Mei Xue1,3, Jiao Bai1,3, Hui-Ming Hua1,3, Xiao-Qiu Liu4, Zhan-Lin Li5,6.
Abstract
Three new xanthones, paucinervins H-J (1-3), as well as eleven known compounds (4-14), were isolated from the leaves of Garcinia paucinervis. The structures of the new compounds (1-3) were elucidated by 1D, 2D NMR spectra and HR ESIMS. In vitro antiproliferative activity against human promyelocytic leukemia HL-60 cells was tested, among which, compounds 2, 5, 6 and 7 exhibited strong growth inhibitory effects with GI50 values ranging from 1.30 to 9.08 μM, respectively. Preliminary SARs were also discussed.Entities:
Keywords: Cytotoxic activity; Garcinia paucinervis; Guttiferae; Xanthone
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Year: 2015 PMID： 26659874 DOI： 10.1007/s12272-015-0692-6
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946