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Literature DB >> 26659842

BLT1: a promising therapeutic approach for atherosclerosis.

P Zeng¹, J Yang².

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2015 PMID： 26659842 DOI： 10.1007/s00059-015-4388-y

Source DB: PubMed Journal: Herz ISSN： 0340-9937 Impact factor: 1.443

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8 in total

1. Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.

Authors: Magnus Bäck; De-xiu Bu; Robert Bränström; Yuri Sheikine; Zhong-Qun Yan; Göran K Hansson
Journal: Proc Natl Acad Sci U S A Date: 2005-11-17 Impact factor: 11.205

2. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice.

Authors: Robert J Aiello; Patricia-Ann Bourassa; Saralyn Lindsey; Weifan Weng; Ann Freeman; Henry J Showell
Journal: Arterioscler Thromb Vasc Biol Date: 2002-03-01 Impact factor: 8.311

3. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.

Authors: Eric A Heller; Emerson Liu; Andrew M Tager; Sumita Sinha; Jesse D Roberts; Stephanie L Koehn; Peter Libby; Elena Rabkin Aikawa; Ji Qiu Chen; Paul Huang; Mason W Freeman; Kathryn J Moore; Andrew D Luster; Robert E Gerszten
Journal: Circulation Date: 2005-07-26 Impact factor: 29.690

BLT1: a promising therapeutic approach for atherosclerosis.

1. Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.

2. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice.

3. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.

4. Leukotriene B4 mediates vascular smooth muscle cell migration through αvβ3 integrin transactivation.

Review 5. Leukotriene receptors in atherosclerosis.

6. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms.

7. The contractile action of leukotriene B4 in the guinea-pig lung involves a vascular component.

8. BLT1 antagonist LSN2792613 reduces infarct size in a mouse model of myocardial ischaemia-reperfusion injury.