Literature DB >> 26659091

Role of the TWEAK/Fn14 pathway in autoimmune diseases.

Wang-Dong Xu1, Yi Zhao1, Yi Liu2.   

Abstract

TNF-like weak inducer of apoptosis (TWEAK) is a member of the TNFSF ligands, initially synthesized as a type II transmembrane protein. TWEAK signaling occurs via binding to Fn14, a type I transmembrane receptor belonging to the TNF receptor superfamily. TWEAK/Fn14 activation controls several cellular responses, including proliferation, angiogenesis, induction of inflammatory cytokines. Studies have indicated that expression of TWEAK/Fn14 was dysregulated in autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease. Functional analysis suggested that TWEAK/Fn14 may play an important role in the development of these diseases. In this review, we discuss the TWEAK/Fn14 pathway and its significant role in autoimmune disorders. The information obtained may lead to a better understanding of the insights into TWEAK/Fn14 in these autoimmune diseases.

Entities:  

Keywords:  Autoimmune; Fn14; TWEAK

Mesh：

Substances：

Year:  2016        PMID： 26659091     DOI： 10.1007/s12026-015-8761-y

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  51 in total

1.  TWEAK attenuates the transition from innate to adaptive immunity.

Authors:  Heather Maecker; Eugene Varfolomeev; Frank Kischkel; David Lawrence; Heidi LeBlanc; Wyne Lee; Stephen Hurst; Dimitry Danilenko; Jun Li; Ellen Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi
Journal:  Cell       Date:  2005-12-02       Impact factor: 41.582

Review 2.  Immune therapies of autoimmune diseases: are we approaching a real cure?

Authors:  Lucienne Chatenoud
Journal:  Curr Opin Immunol       Date:  2006-09-29       Impact factor: 7.486

Review 3.  Interferon regulatory factor 5 and autoimmune lupus.

Authors:  Wang-Dong Xu; Hai-Feng Pan; Yuekang Xu; Dong-Qing Ye
Journal:  Expert Rev Mol Med       Date:  2013-07-24       Impact factor: 5.600

4.  Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis.

Authors:  Yumin Xia; Leal C Herlitz; Simona Gindea; Jing Wen; Rahul D Pawar; Alexander Misharin; Harris Perlman; Lan Wu; Ping Wu; Jennifer S Michaelson; Linda C Burkly; Chaim Putterman
Journal:  J Am Soc Nephrol       Date:  2014-09-30       Impact factor: 10.121

5.  TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast.

Authors:  Alvaro C Ucero; Alberto Benito-Martin; Isabel Fuentes-Calvo; Beatriz Santamaria; Julia Blanco; Jose M Lopez-Novoa; Marta Ruiz-Ortega; Jesus Egido; Linda C Burkly; Carlos Martinez-Salgado; Alberto Ortiz
Journal:  Biochim Biophys Acta       Date:  2013-06-06

6.  Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis.

Authors:  Amal El-Shehaby; Hanan Darweesh; Mohamed El-Khatib; Mohamed Momtaz; Samar Marzouk; Nashwa El-Shaarawy; Yasser Emad
Journal:  J Clin Immunol       Date:  2011-06-21       Impact factor: 8.317

Review 7.  Emerging approaches for the therapy of autoimmune and chronic inflammatory disease.

Authors:  Andrew P Cope; Marc Feldmann
Journal:  Curr Opin Immunol       Date:  2004-12       Impact factor: 7.486

8.  Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis.

Authors:  Rei Kawashima; Yuki I Kawamura; Tomoyuki Oshio; Aoi Son; Motomi Yamazaki; Teruki Hagiwara; Toshihiko Okada; Kyoko Inagaki-Ohara; Ping Wu; Suzanne Szak; Yutaka J Kawamura; Fumio Konishi; Oki Miyake; Hideaki Yano; Yukio Saito; Linda C Burkly; Taeko Dohi
Journal:  Gastroenterology       Date:  2011-09-03       Impact factor: 22.682

Review 9.  The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity.

Authors:  Sean Campbell; Jennifer Michaelson; Linda Burkly; Chaim Putterman
Journal:  Front Biosci       Date:  2004-09-01

10.  Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway.

Authors:  Jing Wen; Yumin Xia; Ariel Stock; Jennifer S Michaelson; Linda C Burkly; Maria Gulinello; Chaim Putterman
Journal:  J Autoimmun       Date:  2013-04-08       Impact factor: 7.094
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  13 in total

1.  [Methylation status and expression of TWEAK gene promoter region in peripheral blood of patients with rheumatoid arthritis].

Authors:  X Lou; L Liao; X J Li; N Wang; S Liu; R M Cui; J Xu
Journal:  Beijing Da Xue Xue Bao Yi Xue Ban       Date:  2021-12-18

2.  Regulation of Fn14 Receptor and NF-κB Underlies Inflammation in Meniere's Disease.

Authors:  Lidia Frejo; Teresa Requena; Satoshi Okawa; Alvaro Gallego-Martinez; Manuel Martinez-Bueno; Ismael Aran; Angel Batuecas-Caletrio; Jesus Benitez-Rosario; Juan M Espinosa-Sanchez; Jesus José Fraile-Rodrigo; Ana María García-Arumi; Rocío González-Aguado; Pedro Marques; Eduardo Martin-Sanz; Nicolas Perez-Fernandez; Paz Pérez-Vázquez; Herminio Perez-Garrigues; Sofía Santos-Perez; Andres Soto-Varela; Maria C Tapia; Gabriel Trinidad-Ruiz; Antonio Del Sol; Marta E Alarcon Riquelme; Jose A Lopez-Escamez
Journal:  Front Immunol       Date:  2017-12-13       Impact factor: 7.561

Review 3.  TWEAK/Fn14 Activation Participates in Skin Inflammation.

Authors:  Qilu Liu; Shengxiang Xiao; Yumin Xia
Journal:  Mediators Inflamm       Date:  2017-09-06       Impact factor: 4.711

Review 4.  Towards personalized medicine in Ménière's disease.

Authors:  Jose Antonio Lopez-Escamez; Angel Batuecas-Caletrio; Alexandre Bisdorff
Journal:  F1000Res       Date:  2018-08-15

5.  Tumor Necrosis Factor-like Weak Inducer of Apoptosis: A Novel Serum Marker in Patients with Severe Alopecia.

Authors:  Abdul-Aziz Ibrahim Al Taweel; Ahmed Mohamed Hamed; Amira Mohamed Noureldin Abdelrahman; Mona Nady Ibrahim Hassan
Journal:  Int J Trichology       Date:  2019 May-Jun

6.  Hepatic progenitor cell activation is induced by the depletion of the gut microbiome in mice.

Authors:  Fei Wang; Nan-Nan Sun; Lan-Lan Li; Wan-Wan Zhu; Jianbo Xiu; Yan Shen; Qi Xu
Journal:  Microbiologyopen       Date:  2019-05-16       Impact factor: 3.139

7.  Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome.

Authors:  Sule Cilekar; Selvihan Beysel; Savas Karatas; Aydin Balci; Kursad Akaslan; Ali Uncu
Journal:  Sci Rep       Date:  2021-11-11       Impact factor: 4.379

Review 8.  Cytokines and Inflammation in Meniere Disease.

Authors:  Lidia Frejo; Jose Antonio Lopez-Escamez
Journal:  Clin Exp Otorhinolaryngol       Date:  2022-02-08       Impact factor: 3.372

9.  Is serum TWEAK a useful biomarker of neuropsychiatric systemic lupus erythematosus?

Authors:  V Balajkova; M Olejarova; R Moravcova; P Kozelek; M Posmurova; H Hulejova; L Senolt
Journal:  Physiol Res       Date:  2020-03-23       Impact factor: 1.881

10.  Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis.

Authors:  Xuening Wang; Dan Cheng; Guanglei Hu; Lili Liang; Fei Tan; Tong Xiao; Shengxiang Xiao; Yumin Xia
Journal:  Mediators Inflamm       Date:  2019-12-05       Impact factor: 4.711
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