Literature DB >> 26658638

Syntheses and biomedical applications of hollow micro-/nano-spheres with large-through-holes.

Yinsong Si1, Min Chen1, Limin Wu1.   

Abstract

Hollow micro-/nano-spheres with large-through-holes in shells (denoted as HMLS) have demonstrated great potential in biomedical applications owing to the combination of hollow structure and their porous shells. In this review, we provide a comprehensive overview of synthesis methods of HMLS obtained from the template-directed approach, shell-breaking method, Ostwald ripening and galvanic replacement primarily based on the formation mechanism of the large-through-holes in the shell. We further discuss the biomedical applications of HMLS including guest adsorption and encapsulation of proteins, drug/gene delivery, biomedical imaging, and theranostics. We conclude this review with some perspectives on the future research and development of the HMLS with desired morphologies and properties.

Mesh：

Year:  2016        PMID： 26658638     DOI： 10.1039/c5cs00695c

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  11 in total

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