Literature DB >> 26657408

Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC.

Jie Zhou1, Pei Luo2, Shanshan Chen2, Lingchang Meng2, Chong Sun2, Qiuzheng Du2, Fang Sun2.   

Abstract

A stereoselective high performance liquid chromatography method has been developed for the chiral separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine. The effects of mobile phase additive, column temperature and flow rate on the retention time and resolution were studied. Enantiomeric separation of cetirizine, doxylamine and hydroxyzine were achieved on cellulose tris-(3,5-dichlorophenylcarbamate) immobilized on silica gel chiral stationary phase known as Chiralpak IC (RS = 3.74, RS = 1.85 and RS = 1.74, respectively).
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Year:  2015        PMID： 26657408      PMCID： PMC4885385          DOI： 10.1093/chromsci/bmv177

Source DB:  PubMed          Journal:  J Chromatogr Sci        ISSN： 0021-9665            Impact factor:   1.618


  14 in total

1.  Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.

Authors:  Derong Zhu; Xia Li; Jinying Sun; Tianyan You
Journal:  Talanta       Date:  2011-10-31       Impact factor: 6.057

2.  Preparation and chiral recognition in HPLC of cellulose 3,5-dichlorophenylcarbamates immobilized onto silica gel.

Authors:  Hai-tao Qu; Jun-qing Li; Guang-shun Wu; Jun Shen; Xian-de Shen; Yoshio Okamoto
Journal:  J Sep Sci       Date:  2011-01-31       Impact factor: 3.645

3.  Complementary enantiorecognition patterns and specific method optimization aspects on immobilized polysaccharide-derived chiral stationary phases.

Authors:  Tong Zhang; Pilar Franco; Dung Nguyen; Ryota Hamasaki; Shoji Miyamoto; Atsushi Ohnishi; Tatsushi Murakami
Journal:  J Chromatogr A       Date:  2012-09-26       Impact factor: 4.759

4.  Chiral separation and quantitation of cetirizine and hydroxyzine by maltodextrin-mediated CE in human plasma: effect of zwitterionic property of cetirizine on enantioseparation.

Authors:  Saeed Nojavan; Ali Reza Fakhari
Journal:  Electrophoresis       Date:  2011-02-16       Impact factor: 3.535

5.  Chiral separation of dioxopromethazine in eye drops by CZE with charged cyclodextrin.

Authors:  Peter Mikus; Iva Valásková; Emil Havránek
Journal:  J Pharm Biomed Anal       Date:  2003-09-19       Impact factor: 3.935

6.  Direct high-performance liquid chromatography enantioseparation of terazosin on an immobilised polysaccharide-based chiral stationary phase under polar organic and reversed-phase conditions.

Authors:  Rosella Ferretti; Bruno Gallinella; Francesco La Torre; Leo Zanitti; Luciana Turchetto; Antonina Mosca; Roberto Cirilli
Journal:  J Chromatogr A       Date:  2009-05-21       Impact factor: 4.759

7.  [Study on the enantiomer separation of cetirizine dihydrochloride using proteinate- and amylose-based chiral stationary phase].

Authors:  Zhe-feng Zhang; Geng-liang Yang; Gui-jian Liang; Yu Zhou; Yi Chen
Journal:  Yao Xue Xue Bao       Date:  2004-03

8.  Comparison of chiral separation of basic drugs in capillary electrophoresis and liquid chromatography using neutral and negatively charged cyclodextrins.

Authors:  Arkadiusz Kwaterczak; Kazimiera Duszczyk; Anna Bielejewska
Journal:  Anal Chim Acta       Date:  2009-05-05       Impact factor: 6.558

9.  Enantioseparation of cetirizine by sulfated-beta-cyclodextrin-mediated capillary electrophoresis.

Authors:  Yu-Wei Chou; Wei-Shan Huang; Chen-Chun Ko; Su-Hwei Chen
Journal:  J Sep Sci       Date:  2008-03       Impact factor: 3.645

10.  Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels.

Authors:  Akiko Imaizumi; Tamihiro Kawakami; Fumiko Murakami; Yoshinao Soma; Masako Mizoguchi
Journal:  J Dermatol Sci       Date:  2003-10       Impact factor: 4.563
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