| Literature DB >> 26657269 |
Stevanus Hiendrawan1, Bambang Veriansyah2, Edward Widjojokusumo2, Sundani Nurono Soewandhi3, Saleh Wikarsa3, Raymond R Tjandrawinata4.
Abstract
We report novel pharmaceutical cocrystal of a popular antipyretic drug paracetamol (PCA) with coformer 5-nitroisophhthalic acid (5NIP) to improve its tabletability. The cocrystal (PCA-5NIP at molar ratio of 1:1) was synthesized by solvent evaporation technique using methanol as solvent. The physicochemical properties of cocrystal were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), fourier transform infrared spectroscopy (FTIR), hot stage polarized microscopy (HSPM) and scanning electron microscopy (SEM). Stability of the cocrystal was assessed by storing them at 40°C/75% RH for one month. Compared to PCA, the cocrystal displayed superior tableting performance. PCA-5NIP cocrystal showed a similar dissolution profile as compared to PCA and exhibited good stability. This study showed the utility of PCA-5NIP cocrystal for improving mechanical properties of PCA.Entities:
Keywords: 5-Nitroisophhthalic acid; 5-Nitroisophthalic acid (PubChem CID: 12069); Acetonitrille (PubChem CID: 6342); Cocrystal; Dissolution rate; Mechanical properties; Methanol (PubChem CID: 887); Paracetamol; Paracetamol (PubChem CID: 1983); Potassium dihydrogen phosphate (PubChem CID: 516951); Sodium hydroxide (PubChem CID: 14798)
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Year: 2015 PMID： 26657269 DOI： 10.1016/j.ijpharm.2015.12.001
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875