Literature DB >> 26657058

Transient receptor potential channel C5 in cancer chemoresistance.

Dong-xu He1, Xin Ma2.   

Abstract

The transient receptor potential (TRP) superfamily contains at least 28 homologs in mammalian. These proteins form TRP channels are permeable to monovalent and divalent cations and participate in a variety of physiological functions. Dysregulation of TRP channels is responsible for numerous diseases. This review provides a brief short overview of mammalian TRP channels with a focus on TRPC5 and its role in cancers. Dysregulation of TRPC5 interrupts Ca(2+) homeostasis in cancer cells, which activates signaling pathways that are highly associated with cancer progression, especially cancer chemoresistance. Based on the important role of TRPC5, we also discuss the potential of TRPC5 as a target for therapeutic intervention. Either direct targeting of TRPC5 or indirect interruption of TRPC5-related signaling pathways may effectively overcome cancer chemoresistance.

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Year:  2015        PMID： 26657058      PMCID： PMC4722981          DOI： 10.1038/aps.2015.109

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  51 in total

1.  Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5.

Authors:  M Schaefer; T D Plant; A G Obukhov; T Hofmann; T Gudermann; G Schultz
Journal:  J Biol Chem       Date:  2000-06-09       Impact factor: 5.157

2.  Relaxed selective pressure on an essential component of pheromone transduction in primate evolution.

Authors:  Emily R Liman; Hideki Innan
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-11       Impact factor: 11.205

Review 3.  The mammalian TRPC cation channels.

Authors:  Guillermo Vazquez; Barbara J Wedel; Omar Aziz; Mohamed Trebak; James W Putney
Journal:  Biochim Biophys Acta       Date:  2004-12-06

4.  Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder.

Authors:  Massimo Lazzeri; Maria Giuliana Vannucchi; Michele Spinelli; Elisa Bizzoco; Patrizia Beneforti; Damiano Turini; Maria-Simonetta Faussone-Pellegrini
Journal:  Eur Urol       Date:  2005-10       Impact factor: 20.096

5.  TRPC1 and TRPC5 form a novel cation channel in mammalian brain.

Authors:  C Strübing; G Krapivinsky; L Krapivinsky; D E Clapham
Journal:  Neuron       Date:  2001-03       Impact factor: 17.173

6.  Inhibition of transient receptor potential channel 5 reverses 5-Fluorouracil resistance in human colorectal cancer cells.

Authors:  Teng Wang; Zhen Chen; Yifei Zhu; Qiongxi Pan; Yanjun Liu; Xiaowei Qi; Linfang Jin; Jian Jin; Xin Ma; Dong Hua
Journal:  J Biol Chem       Date:  2014-11-17       Impact factor: 5.157

7.  Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.

Authors:  Stéphanie Thebault; Loïc Lemonnier; Gabriel Bidaux; Matthieu Flourakis; Alexis Bavencoffe; Dimitri Gordienko; Morad Roudbaraki; Philippe Delcourt; Yuri Panchin; Yaroslav Shuba; Roman Skryma; Natalia Prevarskaya
Journal:  J Biol Chem       Date:  2005-09-20       Impact factor: 5.157

8.  Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth.

Authors:  Silke Jung; Anja Mühle; Michael Schaefer; Rainer Strotmann; Gunter Schultz; Tim D Plant
Journal:  J Biol Chem       Date:  2002-11-26       Impact factor: 5.157

9.  Contribution of transient receptor potential channels to the control of GABA release from dendrites.

Authors:  Thomas Munsch; Marc Freichel; Veit Flockerzi; Hans-Christian Pape
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-10       Impact factor: 11.205

10.  Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing.

Authors:  Kate V Everett; Barry A Chioza; Christina Georgoula; Ashley Reece; R Mark Gardiner; Eddie M K Chung
Journal:  Hum Genet       Date:  2009-12       Impact factor: 4.132
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  7 in total

1.  Ion channels research in the post-genomic era.

Authors:  Bernard Attali; Zhao-Bing Gao
Journal:  Acta Pharmacol Sin       Date:  2016-01       Impact factor: 6.150

Review 2.  TRPC channels: Structure, function, regulation and recent advances in small molecular probes.

Authors:  Hongbo Wang; Xiaoding Cheng; Jinbin Tian; Yuling Xiao; Tian Tian; Fuchun Xu; Xuechuan Hong; Michael X Zhu
Journal:  Pharmacol Ther       Date:  2020-01-28       Impact factor: 12.310

3.  Pan-cancer clinical and molecular analysis of racial disparities.

Authors:  Olivia D Lara; Ying Wang; Amma Asare; Tao Xu; Hua-Sheng Chiu; Yuexin Liu; Wei Hu; Pavel Sumazin; Shitanshu Uppal; Lin Zhang; J Alejandro Rauh-Hain; Anil K Sood
Journal:  Cancer       Date:  2019-11-15       Impact factor: 6.860

Review 4.  The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies.

Authors:  Tiecheng Zhong; Wenxin Zhang; Hongjie Guo; Xiaohui Pan; Xi Chen; Qiaojun He; Bo Yang; Ling Ding
Journal:  Acta Pharm Sin B       Date:  2021-11-05       Impact factor: 14.903

Review 5.  Endothelial Ca2+ Signaling and the Resistance to Anticancer Treatments: Partners in Crime.

Authors:  Francesco Moccia
Journal:  Int J Mol Sci       Date:  2018-01-11       Impact factor: 5.923

Review 6.  Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease.

Authors:  Aisling Minard; Claudia C Bauer; David J Wright; Hussein N Rubaiy; Katsuhiko Muraki; David J Beech; Robin S Bon
Journal:  Cells       Date:  2018-06-01       Impact factor: 6.600

7.  KCa channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549).

Authors:  Felix Glaser; Petra Hundehege; Etmar Bulk; Luca Matteo Todesca; Sandra Schimmelpfennig; Elke Nass; Thomas Budde; Sven G Meuth; Albrecht Schwab
Journal:  Sci Rep       Date:  2021-09-15       Impact factor: 4.379
  7 in total

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