Ofir Artzi1, Christoforos Loizides, Ines Verner, Marina Landau. 1. *Tel Aviv Sourasky Medical Center, Department of Dermatology, The Sackler School of Medicine, Tel Aviv, Israel; †Dr. Verner Clinic of Dermatology & Aesthetics, Kiriat Ono, Israel; ‡Wolfson Medical Center, The Sackler School of Medicine, Tel Aviv, Israel.
Abstract
BACKGROUND: Late reactions to hyaluronic acid (HA)-based fillers have a recorded rate of 0.02%. The recent experience with a newly introduced filler in the tear trough area and the lips showed higher rate of reactions with a tendency to persistency and recurrences. OBJECTIVE: To delineate the features of reactions to this newly introduced filler. MATERIALS AND METHODS: Medical records of 400 patients (360 women and 40 men; average age = 49.6 years) were examined in this retrospective study. Juvéderm Volbella (HA-Vb) filler was injected only into the tear trough area or lips. Other HA-based products were used in other areas of the face. RESULTS: Seventeen patients (4.25%) developed prolonged (up to 11 months) and recurrent (average: 3.17 episodes) late (average onset: 8.41 weeks after the injection) inflammatory cutaneous reactions. CONCLUSION: The incidence of late reactions to HA-based fillers varies between products. The authors are reporting an exceptionally high rate of cutaneous reactions for this newly introduced filler. In the authors' experience, broad-spectrum antibiotics in conjunction with repeated high-dose hyaluronidase injections into the inflammatory nodules were effective treatments.
BACKGROUND: Late reactions to hyaluronic acid (HA)-based fillers have a recorded rate of 0.02%. The recent experience with a newly introduced filler in the tear trough area and the lips showed higher rate of reactions with a tendency to persistency and recurrences. OBJECTIVE: To delineate the features of reactions to this newly introduced filler. MATERIALS AND METHODS: Medical records of 400 patients (360 women and 40 men; average age = 49.6 years) were examined in this retrospective study. Juvéderm Volbella (HA-Vb) filler was injected only into the tear trough area or lips. Other HA-based products were used in other areas of the face. RESULTS: Seventeen patients (4.25%) developed prolonged (up to 11 months) and recurrent (average: 3.17 episodes) late (average onset: 8.41 weeks after the injection) inflammatory cutaneous reactions. CONCLUSION: The incidence of late reactions to HA-based fillers varies between products. The authors are reporting an exceptionally high rate of cutaneous reactions for this newly introduced filler. In the authors' experience, broad-spectrum antibiotics in conjunction with repeated high-dose hyaluronidase injections into the inflammatory nodules were effective treatments.
Authors: Wolfgang G Philipp-Dormston; Greg J Goodman; Koenraad De Boulle; Arthur Swift; Claudio Delorenzi; Derek Jones; Izolda Heydenrych; Ada Trindade De Almeida; Rami K Batniji Journal: Plast Reconstr Surg Glob Open Date: 2020-04-29
Authors: Ofir Artzi; Joel L Cohen; Jeffrey S Dover; Atchima Suwanchinda; Tatjana Pavicic; Marina Landau; Greg J Goodman; Sahar Ghannam; Firas Al Niaimi; Jani A J van Loghem; Kate Goldie; Sonja Sattler; Daniel Cassuto; Ting Song Lim; Rungsima Wanitphakdeedecha; Ines Verner; Tanja C Fischer; Vivian Bucay; Eli Sprecher; Dana Shalmon Journal: Clin Cosmet Investig Dermatol Date: 2020-05-18