Vanessa B Sheppard1, Jennifer Hicks2, Kepher Makambi3, Alejandra Hurtado-de-Mendoza4, Wendy Demark-Wahnefried5, Lucile Adams-Campbell2. 1. Breast Cancer Program, Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven St., NW Suite 4100, Washington, DC 20007, USA; Office of Minority Health & Health Disparities Research, Lombardi Comprehensive Cancer Center, Georgetown University, 1000 New Jersey Ave., SE, Washington, DC 20003, USA. Electronic address: vls3@georgetown.edu. 2. Office of Minority Health & Health Disparities Research, Lombardi Comprehensive Cancer Center, Georgetown University, 1000 New Jersey Ave., SE, Washington, DC 20003, USA. 3. Department of Biostatistics, Georgetown University, 4000 Reservoir Rd., NW, Washington, DC 20057, USA. 4. Breast Cancer Program, Lombardi Comprehensive Cancer Center, Georgetown University, 3300 Whitehaven St., NW Suite 4100, Washington, DC 20007, USA. 5. University of Alabama at Birmingham Comprehensive Cancer Center, 1824 6th Ave S, Birmingham, AL, 35233, USA.
Abstract
PURPOSE:Black breast cancer survivors have high rates of obesity and low physical activity levels. Little is known about the acceptability and feasibility of interventions in this population. OBJECTIVE: A two-arm RCT was launched to assess the efficacy of a culturally targeted 12-week multimodal lifestyle intervention in overweight and obese black survivors. METHODS: Intervention components included nutrition education, exercise groups, and survivor-led motivational interviewing phone sessions. The analytic sample included women who completed the trial (intervention n=10; control n=12). Anthropometric measures, physical activity, and VO2max were assessed at baseline and follow-up. Change scores (intervention vs. control) were assessed with Wilcoxon rank-sum tests. A process evaluation assessed intervention acceptability. RESULTS:Overall adherence was 70% and overall satisfaction was high (86%). Despite the 5% weight loss target, the intervention group lost 0.8% but BMI improved. Total physical activity levels increased in the intervention vs. control arm (+3501METmin/week vs. +965METmin/week, respectively). VO2max improved in the intervention group (+0.10±1.03kg/L/min). Intervention participants reduced energy intake (-207.3±31.5kcals) and showed improvements in fat intake (-15.5±3.8g), fiber (+3.2±1.2g) and % energy from fat (-4.8±3.1%). Survivors suggested providing diet/exercise information within a cancer context. CONCLUSIONS: Group and individualized intervention strategies are acceptable to black survivors. Observed differences between self-report and objective outcomes may suggest reporting bias or changes in body composition. Increasing supervised intervention components and assessment of body composition will be important for future trials.
RCT Entities:
PURPOSE: Black breast cancer survivors have high rates of obesity and low physical activity levels. Little is known about the acceptability and feasibility of interventions in this population. OBJECTIVE: A two-arm RCT was launched to assess the efficacy of a culturally targeted 12-week multimodal lifestyle intervention in overweight and obese black survivors. METHODS: Intervention components included nutrition education, exercise groups, and survivor-led motivational interviewing phone sessions. The analytic sample included women who completed the trial (intervention n=10; control n=12). Anthropometric measures, physical activity, and VO2max were assessed at baseline and follow-up. Change scores (intervention vs. control) were assessed with Wilcoxon rank-sum tests. A process evaluation assessed intervention acceptability. RESULTS: Overall adherence was 70% and overall satisfaction was high (86%). Despite the 5% weight loss target, the intervention group lost 0.8% but BMI improved. Total physical activity levels increased in the intervention vs. control arm (+3501METmin/week vs. +965METmin/week, respectively). VO2max improved in the intervention group (+0.10±1.03kg/L/min). Intervention participants reduced energy intake (-207.3±31.5kcals) and showed improvements in fat intake (-15.5±3.8g), fiber (+3.2±1.2g) and % energy from fat (-4.8±3.1%). Survivors suggested providing diet/exercise information within a cancer context. CONCLUSIONS: Group and individualized intervention strategies are acceptable to black survivors. Observed differences between self-report and objective outcomes may suggest reporting bias or changes in body composition. Increasing supervised intervention components and assessment of body composition will be important for future trials.
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