| Literature DB >> 26655335 |
Sachin Suresh Bhojgude1, Dnyaneshwar R Baviskar1, Rajesh G Gonnade1, Akkattu T Biju1.
Abstract
The transition-metal-free multicomponent coupling of arynes, aromatic tertiary amines, and aldehydes proceeding via the aryl to aryl amino group migration has been demonstrated. This protocol allows rapid access to ortho-functionalized tertiary amines in moderate to good yields. Moreover, activated ketones can also be used as the aldehyde component in the present reaction. The similarity of the aryl-aryl tertiary amino group migration with the Smiles rearrangement is striking.Entities:
Year: 2015 PMID： 26655335 DOI： 10.1021/acs.orglett.5b03319
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005