| Literature DB >> 26654753 |
Samira S Valvassori1, Gustavo C Dal-Pont2, Amanda V Steckert2, Roger B Varela2, Jéssica Lopes-Borges2, Edemilson Mariot2, Wilson R Resende2, Camila O Arent2, André F Carvalho3, João Quevedo4.
Abstract
Studies have consistently reported the participation of oxidative stress in bipolar disorder (BD). Evidence indicates that epigenetic regulations have been implicated in the pathophysiology of mood disorders. Considering these evidences, the present study aimed to investigate the effects of sodium butyrate (SB), a histone deacetylase (HDAC)inhibitor, on manic-like behavior and oxidative stress parameters (TBARS and protein carbonyl content and SOD and CAT activities) in frontal cortex and hippocampus of rats subjected to the animal model of mania induced by intracerebroventricular (ICV) ouabain administration.The results showed that SB reversed ouabain-induced hyperactivity, which represents a manic-like behavior in rats. In addition, the ouabain ICV administration induced oxidative damage to lipid and protein and alters antioxidant enzymes activity in all brain structures analyzed. The treatment with SB was able to reversesboth behavioral and oxidative stress parameters alteration induced by ouabain.In conclusion, we suggest that SB can be considered a potential new mood stabilizer by acts on manic-like behavior and regulatesthe antioxidant enzyme activities, protecting the brain against oxidative damage.Entities:
Keywords: Bipolar disorder; Ouabain; Oxidative stress; Sodium butyrate
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Year: 2015 PMID： 26654753 DOI： 10.1016/j.psychres.2015.11.017
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222