Literature DB >> 26654278

A Door Opens for Fibrodysplasia Ossificans Progressiva.

Takenobu Katagiri1.   

Abstract

Fibrodysplasia ossificans progressiva (FOP), characterized by extra bone formation in soft tissues, is caused by a gain-of-function mutation in ACVR1, a transmembrane receptor. Recently, a potential treatment was developed by identifying a novel molecular mechanism underlying bone formation in FOP. These findings have opened the door to beating FOP.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  activin; bone morphogenetic protein (BMP); heterotopic ossification; intracellular signaling; ligand; receptor

Mesh：

Year:  2015        PMID： 26654278     DOI： 10.1016/j.tibs.2015.11.010

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  7 in total

1.  Notch signaling pathway promotes osteogenic differentiation of mesenchymal stem cells by enhancing BMP9/Smad signaling.

Authors:  Junjie Cao; Yalin Wei; Jing Lian; Lunyun Yang; Xiaoyan Zhang; Jiaying Xie; Qiang Liu; Jinyong Luo; Baicheng He; Min Tang
Journal:  Int J Mol Med       Date:  2017-06-22       Impact factor: 4.101

Review 2.  Discovery of Heterotopic Bone-Inducing Activity in Hard Tissues and the TGF-β Superfamily.

Authors:  Takenobu Katagiri; Sho Tsukamoto; Yutaka Nakachi; Mai Kuratani
Journal:  Int J Mol Sci       Date:  2018-11-13       Impact factor: 5.923

Review 3.  Targeting heterotopic ossification by inhibiting activin receptor‑like kinase 2 function (Review).

Authors:  Fuli Shi; Jiayu Gao; Junrong Zou; Ying Ying; Hui Lin
Journal:  Mol Med Rep       Date:  2019-08-06       Impact factor: 2.952

Review 4.  The role of Activin A in fibrodysplasia ossificans progressiva: a prominent mediator.

Authors:  Hui Lin; Fuli Shi; Jiayu Gao; Ping Hua
Journal:  Biosci Rep       Date:  2019-08-02       Impact factor: 3.840

5.  Non-traumatic myositis ossificans circumscripta in the anterior abdominal wall of a seven-year-old Ugandan child: A case report.

Authors:  Hamdi Mohamed Isse; Senai Goitom Sereke; Mboizi Vincent; Muyinda Zeridah
Journal:  Clin Case Rep       Date:  2022-07-25

Review 6.  Recent Topics in Fibrodysplasia Ossificans Progressiva.

Authors:  Takenobu Katagiri; Sho Tsukamoto; Yutaka Nakachi; Mai Kuratani
Journal:  Endocrinol Metab (Seoul)       Date:  2018-09

Review 7.  Accumulated Knowledge of Activin Receptor-Like Kinase 2 (ALK2)/Activin A Receptor, Type 1 (ACVR1) as a Target for Human Disorders.

Authors:  Takenobu Katagiri; Sho Tsukamoto; Mai Kuratani
Journal:  Biomedicines       Date:  2021-06-26
  7 in total

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