Tasleema Begum1, Paul J Farrelly2, Ross J Craigie3. 1. Department of Paediatric Surgery, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, United Kingdom. 2. Department of Paediatric Surgery, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, United Kingdom; Manchester Academic Heath Science Centre, University of Manchester, United Kingdom. 3. Department of Paediatric Surgery, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, United Kingdom; Manchester Academic Heath Science Centre, University of Manchester, United Kingdom. Electronic address: ross.craigie@cmft.nhs.uk.
Abstract
BACKGROUND: A variety of prosthetic materials are used in the pediatric population for abdominal and chest wall reconstruction. Pediatric experience of non-cross-linked porcine acellular dermal matrix is limited to patients following liver transplantation. We review our outcomes in patients in whom this matrix was used. METHODS: A retrospective analysis of patients who underwent abdominal and chest wall reconstruction with a non-cross-linked porcine acellular dermal matrix (Strattice TM) was performed to assess clinical outcomes. RESULTS: The tissue matrix was used in thirteen patients over a three-year period. Eleven had abdominal wall reconstruction and two underwent chest wall reconstruction. Seven procedures were contaminated at the time of surgery. Median age at insertion was 8.1years (5days-18years) with a median weight of 20.6kg (1.9kg-99kg). The tissue matrix failed in one patient with no unanticipated adverse events. CONCLUSION: Future growth and need for reoperation requires special consideration in pediatric patients undergoing abdominal or thoracic wall reconstruction. Non-cross-linked porcine acellular dermal matrix can be safely used for abdominal and chest wall reconstruction in the pediatric population with a number of advantages over previously utilized materials. In our study, children have a favorable risk profile as compared to published adult series.
BACKGROUND: A variety of prosthetic materials are used in the pediatric population for abdominal and chest wall reconstruction. Pediatric experience of non-cross-linked porcine acellular dermal matrix is limited to patients following liver transplantation. We review our outcomes in patients in whom this matrix was used. METHODS: A retrospective analysis of patients who underwent abdominal and chest wall reconstruction with a non-cross-linked porcine acellular dermal matrix (Strattice TM) was performed to assess clinical outcomes. RESULTS: The tissue matrix was used in thirteen patients over a three-year period. Eleven had abdominal wall reconstruction and two underwent chest wall reconstruction. Seven procedures were contaminated at the time of surgery. Median age at insertion was 8.1years (5days-18years) with a median weight of 20.6kg (1.9kg-99kg). The tissue matrix failed in one patient with no unanticipated adverse events. CONCLUSION: Future growth and need for reoperation requires special consideration in pediatric patients undergoing abdominal or thoracic wall reconstruction. Non-cross-linked porcine acellular dermal matrix can be safely used for abdominal and chest wall reconstruction in the pediatric population with a number of advantages over previously utilized materials. In our study, children have a favorable risk profile as compared to published adult series.
Authors: Lisa J White; Adam J Taylor; Denver M Faulk; Timothy J Keane; Lindsey T Saldin; Janet E Reing; Ilea T Swinehart; Neill J Turner; Buddy D Ratner; Stephen F Badylak Journal: Acta Biomater Date: 2016-12-16 Impact factor: 8.947
Authors: Carlos Delgado-Miguel; Miriam Miguel-Ferrero; Antonio Muñoz-Serrano; Mercedes Díaz; Juan Carlos López-Gutiérrez; Carlos De la Torre Journal: Surg J (N Y) Date: 2022-08-16