| Literature DB >> 26653980 |
Intissar Grissa1, Jaber Elghoul2, Lobna Ezzi1, Sana Chakroun1, Emna Kerkeni1, Mohsen Hassine3, Lassaad El Mir2, Meriem Mehdi1, Hassen Ben Cheikh4, Zohra Haouas1.
Abstract
Titanium dioxide nanoparticles (TiO2 NPs) are widely used for their whiteness and opacity. We investigated the hematological effects and genotoxicity of anatase TiO2 NPs following sub-chronic oral gavage treatment. TiO2-NPs were characterized by X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). Wistar rats were treated with anatase TiO2 NPs by intragastric administration for 60 days. Hematological analysis showed a significant decrease in RBC and HCT and a significant increase in MCV, PLT, MPV and WBC at higher doses. Furthermore, abnormally shaped red cells, sometimes containing micronuclei, and hyper-segmented neutrophil nuclei were observed with TiO2 NPs treatment. The micronucleus test revealed damage to chromosomes in rat bone marrow at 100 and 200mg/kg bw; the comet assay showed significant DNA damage at the same doses.Entities:
Keywords: Anemia; DNA damage; Genotoxicity; Hematopoietic system; Rat; Titanium dioxide nanoparticles
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Year: 2015 PMID： 26653980 DOI： 10.1016/j.mrgentox.2015.09.005
Source DB: PubMed Journal: Mutat Res Genet Toxicol Environ Mutagen ISSN： 1383-5718 Impact factor: 2.873