Jifeng Peng1, Shengnan Qi1, Ping Wang1, Wanyu Li1, Lingxie Song1, Chunxia Liu1,2, Feng Li1,2. 1. Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China. 2. Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
Abstract
AIM: This meta-analysis was conducted to evaluate the diagnostic and prognostic functions of E-cadherin expression in cervical cancer. METHODS: PubMed and other databases were searched for articles associated with E-cadherin and cervical cancer. These articles were published before June 2015 and written in English or Chinese. Random-effects model was used to pool odds ratios on the heterogeneity test in the meta-analysis. RESULTS: All of 20 studies were analyzed, in which 522 (42.6%) subjects exhibited reduced E-cadherin expression. Evaluation of clinicopathologic features showed that the downregulation of E-cadherin was related to the overall survival, clinicopathological parameters and age. CONCLUSION: Downregulation of E-cadherin in cervical cancer patients showed poor overall survival. Therefore, E-cadherinmay be a metastasis-suppressor gene in cervical cancer.
AIM: This meta-analysis was conducted to evaluate the diagnostic and prognostic functions of E-cadherin expression in cervical cancer. METHODS: PubMed and other databases were searched for articles associated with E-cadherin and cervical cancer. These articles were published before June 2015 and written in English or Chinese. Random-effects model was used to pool odds ratios on the heterogeneity test in the meta-analysis. RESULTS: All of 20 studies were analyzed, in which 522 (42.6%) subjects exhibited reduced E-cadherin expression. Evaluation of clinicopathologic features showed that the downregulation of E-cadherin was related to the overall survival, clinicopathological parameters and age. CONCLUSION: Downregulation of E-cadherin in cervical cancerpatients showed poor overall survival. Therefore, E-cadherinmay be a metastasis-suppressor gene in cervical cancer.