Szabolcs Dvoracsko1, Azzurra Stefanucci2, Ettore Novellino3, Adriano Mollica4. 1. Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, 6726, Szeged, Hungary. 2. Dipartimento di Chimica, Sapienza, Università di Roma, P.le A. Moro 5, 00187, Rome, Italy. 3. Dipartimento di Farmacia, Università di Napoli 'Federico II,' Via D. Montesano, 49, 80131, Naples, Italy. 4. Dipartimento di Farmacia, Università di Chieti-Pescara 'G. d'Annunzio,' Via dei Vestini 31, 66100, Chieti, Italy.
Abstract
BACKGROUND: Monodrug therapy has been used with success to fight various pathologies. When one medicine fails, co-administration of two or more drugs at the same time may be successfully applied in the treatment of infections, hypertension, HIV and in many other fields. DISCUSSION: This approach has some weakness related to the pharmacokinetic of the two different substances administered, side effects, possible drug-drug interaction. Bivalent ligand approach would maintain the strength of the multidrug therapy (synergistic effect, lower doses, and little side effects) and overcome the weakness of a co-administration. CONCLUSION: In this review we have described the state-of-the-art of the multitarget approach for the control of pain. Several approaches adopted by different research groups and future perspectives have been discussed.
BACKGROUND: Monodrug therapy has been used with success to fight various pathologies. When one medicine fails, co-administration of two or more drugs at the same time may be successfully applied in the treatment of infections, hypertension, HIV and in many other fields. DISCUSSION: This approach has some weakness related to the pharmacokinetic of the two different substances administered, side effects, possible drug-drug interaction. Bivalent ligand approach would maintain the strength of the multidrug therapy (synergistic effect, lower doses, and little side effects) and overcome the weakness of a co-administration. CONCLUSION: In this review we have described the state-of-the-art of the multitarget approach for the control of pain. Several approaches adopted by different research groups and future perspectives have been discussed.
Authors: Joanna Starnowska; Roberto Costante; Karel Guillemyn; Katarzyna Popiolek-Barczyk; Nga N Chung; Carole Lemieux; Attila Keresztes; Joost Van Duppen; Adriano Mollica; John Streicher; Jozef Vanden Broeck; Peter W Schiller; Dirk Tourwé; Joanna Mika; Steven Ballet; Barbara Przewlocka Journal: ACS Chem Neurosci Date: 2017-07-26 Impact factor: 4.418
Authors: Jolanta Dyniewicz; Piotr F J Lipiński; Piotr Kosson; Anna Leśniak; Marta Bochyńska-Czyż; Adriana Muchowska; Dirk Tourwé; Steven Ballet; Aleksandra Misicka; Andrzej W Lipkowski Journal: ACS Med Chem Lett Date: 2016-11-01 Impact factor: 4.345
Authors: Joanna Matalińska; Piotr F J Lipiński; Piotr Kosson; Katarzyna Kosińska; Aleksandra Misicka Journal: Int J Mol Sci Date: 2020-10-19 Impact factor: 5.923