Literature DB >> 2665247

Regulation of sexual differentiation in drug and steroid metabolism.

P G Zaphiropoulos, A Mode, G Norstedt, J A Gustafsson.   

Abstract

Certain members of the cytochrome P-450 family are expressed at different levels in the livers of male and female rats. Although little is known of the functional significance of these sex differences, progress has been made towards the understanding of the endocrine control of hepatic sex differences in cytochrome P-450 levels. Jan-Ake Gustafsson and colleagues describe a subpopulation of hepatic sexually differentiated P-450s that is regulated by sex differences in growth hormone (GH) secretory pattern. This secretory pattern is in turn regulated by gonadal steroids. These studies demonstrate a novel action of GH and suggest that the hormonal secretory rhythm is pivotal in determination of biological effects.

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Year:  1989        PMID： 2665247     DOI： 10.1016/0165-6147(89)90167-3

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  24 in total

1.  Sulfation and glucuronidation of acetaminophen by cultured hepatocytes reproducing in vivo sex-differences in conjugation on Matrigel and type 1 collagen.

Authors:  R E Kane; J Tector; J J Brems; A Li; D Kaminski
Journal:  In Vitro Cell Dev Biol       Date:  1991-12

2.  Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

Authors:  L M Forrester; C J Henderson; M J Glancey; D J Back; B K Park; S E Ball; N R Kitteringham; A W McLaren; J S Miles; P Skett
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857

3.  Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene.

Authors:  M Yano; E Falvey; F J Gonzalez
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

4.  Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5 alpha-reductase.

Authors:  P Bullock; B Gemzik; D Johnson; P Thomas; A Parkinson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

5.  Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression.

Authors:  Vivaswath S Ayyar; Debra C DuBois; Toshimichi Nakamura; Richard R Almon; William J Jusko
Journal:  J Pharmacol Exp Ther       Date:  2019-06-13       Impact factor: 4.030

6.  The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation.

Authors:  T K Chang; J Teixeira; G Gil; D J Waxman
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

7.  Monoamine oxidase inhibition by L-deprenyl depends on both sex and route of administration in the rat.

Authors:  M P Murphy; P H Wu; N W Milgram; G O Ivy
Journal:  Neurochem Res       Date:  1993-12       Impact factor: 3.996

8.  Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver.

Authors:  P K Srivastava; D J Waxman
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

9.  Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics.

Authors:  K H Lew; E A Ludwig; M A Milad; K Donovan; E Middleton; J J Ferry; W J Jusko
Journal:  Clin Pharmacol Ther       Date:  1993-10       Impact factor: 6.875

10.  1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.

Authors:  G Smith; C J Henderson; M G Parker; R White; R G Bars; C R Wolf
Journal:  Biochem J       Date:  1993-02-01       Impact factor: 3.857
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