| Literature DB >> 26652389 |
Yu Prylutskyy1, A Bychko2, V Sokolova3, S Prylutska2, M Evstigneev4, V Rybalchenko2, M Epple3, P Scharff5.
Abstract
With an aim to elucidate the effects of C60 fullerene complexed with antibiotic doxorubicin (Dox) on model bilipid membranes (BLM), the investigation of the electrical properties of BLM under the action of Dox and C60 fullerene, and of their complex, C60+Dox,was performed. The complex as well as its components exert a clearly detectable influence on BLM, which is concentration-dependent and also depends on phospholipid composition. The mechanism of this effect originates either from intermolecular interaction of the drug with fatty-acid residues of phospholipids, or from membranotropic effects of the drug-induced lipid peroxidation, or from the sum of these two effects. By fluorescence microscopy the entering of C60 + Dox complex into HeLa cells was directly shown.Entities:
Keywords: C(60) fullerene; Current–voltage characteristics; Doxorubicin; Fluorescence microscopy; HeLa cells; Model bilipid membranes
Mesh：
Substances：
Year: 2015 PMID： 26652389 DOI： 10.1016/j.msec.2015.10.049
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328