| Literature DB >> 26652197 |
Xiao-Lu Li, Wen-Fei He, Jia Li, Le-Fu Lan, Xu-Wen Li, Yue-Wei Guo1.
Abstract
Two new laurane-type sesquiterpenoids, debromo-3α-hydroperoxy-3-epiaplysin (1) and debromo-3β-hydroperoxyaplysin (2), together with seven known related compounds (3-9), were isolated from the Chinese red alga Laurencia okamurai. Their structures were elucidated by detailed analysis of spectroscopic data and by comparison with the literature. In bioassay, compounds 2, 4, 8, and 9 exhibited significant PTP1B inhibitory activity with IC50 values ranging from 4.9 to 14.9 μg/ml.Entities:
Keywords: Chinese red algae; Laurencia okamurai; PTP1B inhibitor; laurane; sesquiterpene
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Year: 2015 PMID： 26652197 DOI： 10.1080/10286020.2015.1102135
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569