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Literature DB >> 26651592

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus.

Abstract

Insulin-degrading enzyme (IDE) selectively degrades peptides, such as insulin, amylin, and amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis. IDE defects are linked to the development of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). Structural and biochemical analyses revealed the molecular basis for IDE-mediated destruction of amyloidogenic peptides and this information has been exploited to develop promising inhibitors of IDE to improve glucose homeostasis. However, the inhibition of IDE can also lead to glucose intolerance. In this review, I focus on recent advances regarding our understanding of the structure and function of IDE and the discovery of IDE inhibitors, as well as challenges in developing IDE-based therapy for human diseases, particularly T2DM.

Entities: CellLine Chemical Disease Gene Species

Keywords: Alzheimer's disease; insulin degrading enzyme; small molecule inhibitors; type 2 diabetes mellitus

Mesh：

Substances：

Year: 2015 PMID： 26651592 PMCID： PMC4698235 DOI： 10.1016/j.tem.2015.11.003

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

81 in total

1. Insulin-degrading enzyme: embarking on amyloid destruction.

Authors: I V Kurochkin
Journal: Trends Biochem Sci Date: 2001-07 Impact factor: 13.807

2. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.

Authors: R B DeMattos; K R Bales; D J Cummins; J C Dodart; S M Paul; D M Holtzman
Journal: Proc Natl Acad Sci U S A Date: 2001-07-03 Impact factor: 11.205

Review 3. Glucagon and regulation of glucose metabolism.

Authors: Guoqiang Jiang; Bei B Zhang
Journal: Am J Physiol Endocrinol Metab Date: 2003-04 Impact factor: 4.310

Review 4. Clearing the brain's amyloid cobwebs.

Authors: D J Selkoe
Journal: Neuron Date: 2001-10-25 Impact factor: 17.173

5. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Authors: M D Michael; R N Kulkarni; C Postic; S F Previs; G I Shulman; M A Magnuson; C R Kahn
Journal: Mol Cell Date: 2000-07 Impact factor: 17.970

6. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

Authors: L Bertram; D Blacker; K Mullin; D Keeney; J Jones; S Basu; S Yhu; M G McInnis; R C Go; K Vekrellis; D J Selkoe; A J Saunders; R E Tanzi
Journal: Science Date: 2000-12-22 Impact factor: 47.728

7. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.

Authors: Bonnie C Miller; Elizabeth A Eckman; Kumar Sambamurti; Nicole Dobbs; K Martin Chow; Christopher B Eckman; Louis B Hersh; Dwain L Thiele
Journal: Proc Natl Acad Sci U S A Date: 2003-05-05 Impact factor: 11.205

8. An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures.

Authors: Robert G Bennett; Frederick G Hamel; William C Duckworth
Journal: Diabetes Date: 2003-09 Impact factor: 9.461

9. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

Authors: Wesley Farris; Stefan Mansourian; Yang Chang; Loren Lindsley; Elizabeth A Eckman; Matthew P Frosch; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe; Suzanne Guenette
Journal: Proc Natl Acad Sci U S A Date: 2003-03-12 Impact factor: 11.205

10. The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes.

Authors: S Ghosh; R M Watanabe; T T Valle; E R Hauser; V L Magnuson; C D Langefeld; D S Ally; K L Mohlke; K Silander; K Kohtamäki; P Chines; J Balow; G Birznieks; J Chang; W Eldridge; M R Erdos; Z E Karanjawala; J I Knapp; K Kudelko; C Martin; A Morales-Mena; A Musick; T Musick; C Pfahl; R Porter; J B Rayman
Journal: Am J Hum Genet Date: 2000-10-13 Impact factor: 11.043

43 in total

Review 1. Insulin transport into the brain.

Authors: Sarah M Gray; Eugene J Barrett
Journal: Am J Physiol Cell Physiol Date: 2018-05-30 Impact factor: 4.249

2. The Longest Amyloid-β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme.

Authors: Claire A Krasinski; Qiuchen Zheng; Valerie A Ivancic; Donald E Spratt; Noel D Lazo
Journal: ACS Chem Neurosci Date: 2018-08-03 Impact factor: 4.418

3. Catalytic Mechanism of Amyloid-β Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation.

Authors: Rui Lai; Wei-Jen Tang; Hui Li
Journal: J Chem Inf Model Date: 2018-09-06 Impact factor: 4.956

4. Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.

Authors: Pablo Villa-Pérez; Beatriz Merino; Cristina M Fernández-Díaz; Pilar Cidad; Carmen D Lobatón; Alfredo Moreno; Harrison T Muturi; Hilda E Ghadieh; Sonia M Najjar; Malcolm A Leissring; Irene Cózar-Castellano; Germán Perdomo
Journal: Metabolism Date: 2018-08-08 Impact factor: 8.694

5. The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.

Authors: Diego Sbardella; Grazia R Tundo; Andrea Coletta; Julien Marcoux; Efthymia Ioanna Koufogeorgou; Chiara Ciaccio; Anna M Santoro; Danilo Milardi; Giuseppe Grasso; Paola Cozza; Marie-Pierre Bousquet-Dubouch; Stefano Marini; Massimo Coletta
Journal: Cell Mol Life Sci Date: 2018-03-28 Impact factor: 9.261