Andreas M Bucher1,2, Julian L Wichmann1,2, U Joseph Schoepf3,4, Christopher D Wolla1, Christian Canstein5, Andrew D McQuiston1, Aleksander W Krazinski1, Carlo N De Cecco1,6, Felix G Meinel1,7, Thomas J Vogl2, Lucas L Geyer1,7. 1. Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Drive, Charleston, SC, 29401, USA. 2. Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany. 3. Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Drive, Charleston, SC, 29401, USA. schoepf@musc.edu. 4. Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA. schoepf@musc.edu. 5. CT Division, Siemens Medical Solutions, Malvern, PA, USA. 6. Department of Radiological Sciences, Oncology and Pathology, University of Rome "Sapienza"-Polo Pontino, Latina, Italy. 7. Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Munich, Germany.
Abstract
OBJECTIVES: To assess quantitatively the impact of a novel reconstruction algorithm ("kernel") with beam-hardening correction (BHC) on beam-hardening artefacts of the myocardium at dual-energy CT myocardial perfusion imaging (DE-CTMPI). METHODS: Rest-series of DE-CTMPI examinations from 14 patients were retrospectively analyzed. Six image series were reconstructed for each patient: a) 100 kV, b) 140 kV, and c) linearly blended MIX0.5, each with BHC (D33f kernel) and without (D30f kernel). Seven hundred and fifty-six myocardial regions were assessed. Seven equal regions of interest divided the myocardium in the axial section. Three subdivisions were created within these regions in areas prone to BHA. Reports of SPECT studies performed within 30 days of CT examination were used to confirm the presence and location of true perfusion defects. Paired student t-test was used for statistical evaluation. RESULTS: Overall mean myocardial attenuation was lower using BHC (D30f: 87.3 ± 24.1 HU; D33f: 85.5 ± 21.5 HU; p = 0.009). Overall relative difference from average myocardial attenuation (RDMA) was more homogeneous using BHC (D30f: -0.3 ± 11.4 %; D33f: 0.1 ± 10.1 %; p < 0.001). Changes in RDMA were greatest in the posterobasal myocardium (D30f: -16.2 ± 10.0 %; D33f: 3.4 ± 10.7 %; p < 0.001). CONCLUSIONS: A dedicated reconstruction algorithm with BHC can significantly reduce beam-hardening artefacts in DE-CTMPI. KEY POINTS: • Beam-hardening artefacts (BHA) cause interference with attenuation-based CT myocardial perfusion assessment (CTMPI). • BHA occur mostly in the posterobasal left ventricular wall. • Beam-hardening correction homogenized and decreased mean myocardial attenuation. • BHC can help avoid false-positive findings and increase specificity of static CTMPI.
OBJECTIVES: To assess quantitatively the impact of a novel reconstruction algorithm ("kernel") with beam-hardening correction (BHC) on beam-hardening artefacts of the myocardium at dual-energy CT myocardial perfusion imaging (DE-CTMPI). METHODS: Rest-series of DE-CTMPI examinations from 14 patients were retrospectively analyzed. Six image series were reconstructed for each patient: a) 100 kV, b) 140 kV, and c) linearly blended MIX0.5, each with BHC (D33f kernel) and without (D30f kernel). Seven hundred and fifty-six myocardial regions were assessed. Seven equal regions of interest divided the myocardium in the axial section. Three subdivisions were created within these regions in areas prone to BHA. Reports of SPECT studies performed within 30 days of CT examination were used to confirm the presence and location of true perfusion defects. Paired student t-test was used for statistical evaluation. RESULTS: Overall mean myocardial attenuation was lower using BHC (D30f: 87.3 ± 24.1 HU; D33f: 85.5 ± 21.5 HU; p = 0.009). Overall relative difference from average myocardial attenuation (RDMA) was more homogeneous using BHC (D30f: -0.3 ± 11.4 %; D33f: 0.1 ± 10.1 %; p < 0.001). Changes in RDMA were greatest in the posterobasal myocardium (D30f: -16.2 ± 10.0 %; D33f: 3.4 ± 10.7 %; p < 0.001). CONCLUSIONS: A dedicated reconstruction algorithm with BHC can significantly reduce beam-hardening artefacts in DE-CTMPI. KEY POINTS: • Beam-hardening artefacts (BHA) cause interference with attenuation-based CT myocardial perfusion assessment (CTMPI). • BHA occur mostly in the posterobasal left ventricular wall. • Beam-hardening correction homogenized and decreased mean myocardial attenuation. • BHC can help avoid false-positive findings and increase specificity of static CTMPI.
Authors: Brett S Harris; Carlo N De Cecco; U Joseph Schoepf; Daniel H Steinberg; Richard R Bayer; Aleksander W Krazinski; Kevin T Dyer; Monique K Sandhu; Michael R Zile; Felix G Meinel Journal: Radiology Date: 2014-11-12 Impact factor: 11.105
Authors: Felix G Meinel; Carlo N De Cecco; U Joseph Schoepf; John W Nance; Justin R Silverman; Brian A Flowers; Thomas Henzler Journal: Radiology Date: 2013-11-13 Impact factor: 11.105
Authors: Serena Dell'Aversana; Raffaele Ascione; Marco De Giorgi; Davide Raffaele De Lucia; Renato Cuocolo; Marco Boccalatte; Gerolamo Sibilio; Giovanni Napolitano; Giuseppe Muscogiuri; Sandro Sironi; Giuseppe Di Costanzo; Enrico Cavaglià; Massimo Imbriaco; Andrea Ponsiglione Journal: J Imaging Date: 2022-09-01