Literature DB >> 26650715

Use of posttreatment imaging and biomarkers in survivors of early-stage breast cancer: Inappropriate surveillance or necessary care?

Erin E Hahn1, Tania Tang1, Janet S Lee1, Corrine E Munoz-Plaza1, Ernest Shen1, Braden Rowley2, Jared L Maeda3, David M Mosen4, John C Ruckdeschel2, Michael K Gould1.   

Abstract

BACKGROUND: Advanced imaging and serum biomarkers are commonly used for surveillance in patients with early-stage breast cancer, despite recommendations against this practice. Incentives to perform such low-value testing may be less prominent in integrated health care delivery systems. The purpose of the current study was to evaluate and compare the use of these services within 2 integrated systems: Kaiser Permanente (KP) and Intermountain Healthcare (IH). The authors also sought to distinguish the indication for testing: diagnostic purposes or routine surveillance.
METHODS: Patients with American Joint Committee on Cancer stage 0 to II breast cancer diagnosed between 2009 and 2010 were identified and the use of imaging and biomarker tests over an 18-month period were quantified, starting at 1 year after diagnosis. Chart abstraction was performed on a random sample of patients who received testing to identify the indication for testing. Multivariate regression was used to explore associations with the use of nonrecommended care.
RESULTS: A total of 6585 patients were identified; 22% had stage 0 disease, 44% had stage I disease, and 34% had stage II disease. Overall, 24% of patients received at least 1 imaging test (25% at KP vs 22% at IH; P = .009) and 28% of patients received at least 1 biomarker (36% at KP vs 13% at IH; P<.001). Chart abstraction revealed that 84% of imaging tests were performed to evaluate symptoms or signs. Virtually all biomarkers were ordered for routine surveillance. Stage of disease, medical center that provided the services, and provider experience were found to be significantly associated with the use of biomarkers.
CONCLUSIONS: Advanced imaging was most often performed for appropriate indications, but biomarkers were used for nonrecommended surveillance. Distinguishing between inappropriate use for surveillance and appropriate diagnostic testing is essential when evaluating adherence to recommendations.
© 2015 American Cancer Society.

Entities:  

Keywords:  Choosing Wisely; breast cancer surveillance; guideline adherence; imaging; serum biomarkers

Mesh:

Substances:

Year:  2015        PMID: 26650715     DOI: 10.1002/cncr.29811

Source DB:  PubMed          Journal:  Cancer        ISSN: 0008-543X            Impact factor:   6.860


  13 in total

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3.  Temporal trends and regional variation in the utilization of low-value breast cancer care: has the Choosing Wisely campaign made a difference?

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Authors:  Debra P Ritzwoller; Paul A Fishman; Matthew P Banegas; Nikki M Carroll; Maureen O'Keeffe-Rosetti; Angel M Cronin; Hajime Uno; Mark C Hornbrook; Michael J Hassett
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10.  Patterns of Surveillance Advanced Imaging and Serum Tumor Biomarker Testing Following Launch of the Choosing Wisely Initiative.

Authors:  Randy C Miles; Christoph I Lee; Qin Sun; Aasthaa Bansal; Gary H Lyman; Jennifer M Specht; Catherine R Fedorenko; Mikael Anne Greenwood-Hickman; Scott D Ramsey; Janie M Lee
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