| Literature DB >> 26650690 |
Dong Hang1, Yin Yin1, Jing Han1, Jie Jiang1, Hongxqia Ma1, Shuanghua Xie2, Xiaoshuang Feng2, Kai Zhang3, Zhibin Hu4, Hongbing Shen4, Gary M Clifford5, Min Dai2, Ni Li6.
Abstract
HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.Entities:
Keywords: Case-control study; Cervical cancer; Human papillomavirus 16; Meta-analysis; Variant
Mesh：
Year: 2015 PMID： 26650690 DOI： 10.1016/j.virol.2015.11.016
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616