Literature DB >> 26650391

PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition.

Cecilia Garlanda1, Sebastien Jaillon1, Andrea Doni1, Barbara Bottazzi1, Alberto Mantovani2.   

Abstract

Innate immunity consists of a cellular and a humoral arm. PTX3 is a fluid patter recognition molecule (PRM) with antibody-like properties. Gene targeted mice and genetic associations in humans suggest that PTX3 plays a non-redundant role in resistance against selected pathogens (e.g. Aspergillus fumigatus, Pseudomonas aeruginosa, uropathogenic Escherichia coli) and in the regulation of inflammation. PTX3 acts as an extrinsic oncosuppressor by taming complement elicited tumor-promoting inflammation. Recent results indicate that, by interacting with provisional matrix components, PTX3 contributes to the orchestration of tissue repair. An acidic pH sets PTX3 in a tissue repair mode, while retaining anti-microbial recognition. Based on these data and scattered information on humoral PRM and matrix components, we surmise that matrix and microbial recognition are related functions in evolution.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID： 26650391      PMCID： PMC5414837          DOI： 10.1016/j.coi.2015.11.002

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  52 in total

1.  Aberrant methylation of the 3q25 tumor suppressor gene PTX3 in human esophageal squamous cell carcinoma.

Authors:  Jun-Xiong Wang; Yuan-Long He; Sheng-Tao Zhu; Shuo Yang; Shu-Tian Zhang
Journal:  World J Gastroenterol       Date:  2011-10-07       Impact factor: 5.742

2.  M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules.

Authors:  Evelyne Gout; Christine Moriscot; Andrea Doni; Chantal Dumestre-Pérard; Monique Lacroix; Julien Pérard; Guy Schoehn; Alberto Mantovani; Gérard J Arlaud; Nicole M Thielens
Journal:  J Immunol       Date:  2011-04-13       Impact factor: 5.422

Review 3.  Fibronectin: an enhancer of phagocyte function.

Authors:  R A Proctor
Journal:  Rev Infect Dis       Date:  1987 Jul-Aug

4.  Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β/IL-17A axis.

Authors:  C Ning; Y-Y Li; Y Wang; G-C Han; R-X Wang; H Xiao; X-Y Li; C-M Hou; Y-F Ma; D-S Sheng; B-F Shen; J-N Feng; R-F Guo; Y Li; G-J Chen
Journal:  Mucosal Immunol       Date:  2015-03-04       Impact factor: 7.313

5.  Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer.

Authors:  Roberto Ronca; Patrizia Alessi; Daniela Coltrini; Emanuela Di Salle; Arianna Giacomini; Daria Leali; Michela Corsini; Mirella Belleri; Chiara Tobia; Cecilia Garlanda; Elisa Bonomi; Regina Tardanico; William Vermi; Marco Presta
Journal:  J Pathol       Date:  2013-06       Impact factor: 7.996

6.  Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection.

Authors:  Sébastien Jaillon; Giuseppe Mancuso; Yveline Hamon; Céline Beauvillain; Viorica Cotici; Angelina Midiri; Barbara Bottazzi; Manuela Nebuloni; Cecilia Garlanda; Isabelle Frémaux; Jean-François Gauchat; Philippe Descamps; Concetta Beninati; Alberto Mantovani; Pascale Jeannin; Yves Delneste
Journal:  J Immunol       Date:  2013-07-17       Impact factor: 5.422

7.  The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.

Authors:  You-Wen He; Hong Li; Jun Zhang; Chia-Lin Hsu; Emily Lin; Nu Zhang; Jian Guo; Katherine A Forbush; Michael J Bevan
Journal:  Nat Immunol       Date:  2003-12-14       Impact factor: 25.606

8.  A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.

Authors:  Emma R Job; Barbara Bottazzi; Kirsty R Short; Yi-Mo Deng; Alberto Mantovani; Andrew G Brooks; Patrick C Reading
Journal:  J Immunol       Date:  2013-12-04       Impact factor: 5.422

9.  Amyloid P-component is a constituent of normal human glomerular basement membrane.

Authors:  R F Dyck; C M Lockwood; M Kershaw; N McHugh; V C Duance; M L Baltz; M B Pepys
Journal:  J Exp Med       Date:  1980-11-01       Impact factor: 14.307

10.  Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.

Authors:  Ádám I Csincsi; Anne Kopp; Miklós Zöldi; Zsófia Bánlaki; Barbara Uzonyi; Mario Hebecker; Joseph J E Caesar; Matthew C Pickering; Kenji Daigo; Takao Hamakubo; Susan M Lea; Elena Goicoechea de Jorge; Mihály Józsi
Journal:  J Immunol       Date:  2015-04-08       Impact factor: 5.422
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  20 in total

Review 1.  The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases.

Authors:  Samuel M Gonçalves; Katrien Lagrou; Cláudio Duarte-Oliveira; Johan A Maertens; Cristina Cunha; Agostinho Carvalho
Journal:  Virulence       Date:  2016-11-07       Impact factor: 5.882

2.  Systemic inflammation in acute intermittent porphyria: a case-control study.

Authors:  E Storjord; J A Dahl; A Landsem; H Fure; J K Ludviksen; S Goldbeck-Wood; B O Karlsen; K S Berg; T E Mollnes; E W Nielsen; O-L Brekke
Journal:  Clin Exp Immunol       Date:  2016-12-15       Impact factor: 4.330

3.  Transcriptome Assessment of Erythema Migrans Skin Lesions in Patients With Early Lyme Disease Reveals Predominant Interferon Signaling.

Authors:  Adriana Marques; Ira Schwartz; Gary P Wormser; Yanmei Wang; Ronald L Hornung; Cumhur Y Demirkale; Peter J Munson; Siu-Ping Turk; Carla Williams; Chyi-Chia Richard Lee; Jun Yang; Mary M Petzke
Journal:  J Infect Dis       Date:  2017-12-27       Impact factor: 5.226

4.  Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial.

Authors:  Pietro Caironi; Serge Masson; Tommaso Mauri; Barbara Bottazzi; Roberto Leone; Michela Magnoli; Simona Barlera; Filippo Mamprin; Andrea Fedele; Alberto Mantovani; Gianni Tognoni; Antonio Pesenti; Luciano Gattinoni; Roberto Latini
Journal:  Eur J Clin Invest       Date:  2016-12-14       Impact factor: 4.686

Review 5.  Pentraxins in the activation and regulation of innate immunity.

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Journal:  Immunol Rev       Date:  2016-11       Impact factor: 12.988

6.  rs1840680 single nucleotide polymorphism in Pentraxin 3: a potential protective biomarker of severe community-acquired pneumonia.

Authors:  Qiaojun Zeng; Tiantian Tang; Biru Huang; Shiyi Bu; Yingqi Xiao; Yumeng Dai; Zixin Wei; Linjie Huang; Shanping Jiang
Journal:  J Int Med Res       Date:  2021-04       Impact factor: 1.671

Review 7.  The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

Authors:  Elena Magrini; Alberto Mantovani; Cecilia Garlanda
Journal:  Trends Mol Med       Date:  2016-05-11       Impact factor: 11.951

8.  The Long Pentraxin PTX3 Controls Klebsiella Pneumoniae Severe Infection.

Authors:  Fatemeh Asgari; Domenico Supino; Raffaella Parente; Nadia Polentarutti; Matteo Stravalaci; Remi Porte; Fabio Pasqualini; Marialuisa Barbagallo; Chiara Perucchini; Camilla Recordati; Elena Magrini; Andrea Mariancini; Federica Riva; Alessia Giordano; Sadaf Davoudian; Thierry Roger; Cornelis Van't Veer; Sebastien Jaillon; Alberto Mantovani; Andrea Doni; Cecilia Garlanda
Journal:  Front Immunol       Date:  2021-05-20       Impact factor: 7.561

Review 9.  The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs.

Authors:  Kenji Daigo; Yuichiro Takamatsu; Takao Hamakubo
Journal:  Front Immunol       Date:  2016-09-07       Impact factor: 7.561

Review 10.  The Cell Biology of the Trichosporon-Host Interaction.

Authors:  Cláudio Duarte-Oliveira; Fernando Rodrigues; Samuel M Gonçalves; Gustavo H Goldman; Agostinho Carvalho; Cristina Cunha
Journal:  Front Cell Infect Microbiol       Date:  2017-04-07       Impact factor: 5.293
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