Literature DB >> 26650232

The Na(+)-Taurocholate Cotransporting Polypeptide Traffics with the Epidermal Growth Factor Receptor.

Xintao Wang1, Pijun Wang1, Wenjun Wang1,2, John W Murray1,2, Allan W Wolkoff1,2,3.   

Abstract

Na(+)-taurocholate cotransporting polypeptide (ntcp) mediates bile acid transport, also serving as the hepatitis B virus receptor. It traffics in vesicles along microtubules, requiring activity of protein kinase C (PKC)ζ for motility. We have now found that the epidermal growth factor receptor (EGFR) is the target of PKCζ activity and that EGFR and ntcp colocalize in vesicles. ntcp-containing vesicles that are not associated with EGFR have reduced microtubule-based motility, consistent with intracellular accumulation and reduced surface expression of ntcp in cells following EGFR knockdown.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  bile acid; drug transport; endosome; hepatitis B virus (HBV); microtubule

Mesh：

Substances：

Year:  2016        PMID： 26650232      PMCID： PMC4767556          DOI： 10.1111/tra.12354

Source DB:  PubMed          Journal:  Traffic        ISSN： 1398-9219            Impact factor:   6.215


  49 in total

1.  Reconstitution of ATP-dependent movement of endocytic vesicles along microtubules in vitro: an oscillatory bidirectional process.

Authors:  J W Murray; E Bananis; A W Wolkoff
Journal:  Mol Biol Cell       Date:  2000-02       Impact factor: 4.138

2.  A novel casein kinase 2 alpha-subunit regulates membrane protein traffic in the human hepatoma cell line HuH-7.

Authors:  X Shi; B Potvin; T Huang; P Hilgard; D C Spray; S O Suadicani; A W Wolkoff; P Stanley; R J Stockert
Journal:  J Biol Chem       Date:  2000-10-18       Impact factor: 5.157

3.  Immunofluorescence microchamber technique for characterizing isolated organelles.

Authors:  John W Murray; Eustratios Bananis; Allan W Wolkoff
Journal:  Anal Biochem       Date:  2002-06-01       Impact factor: 3.365

4.  Regulation of early endocytic vesicle motility and fission in a reconstituted system.

Authors:  Eustratios Bananis; John W Murray; Richard J Stockert; Peter Satir; Allan W Wolkoff
Journal:  J Cell Sci       Date:  2003-05-20       Impact factor: 5.285

Review 5.  Bile salt transporters.

Authors:  Peter J Meier; B Stieger
Journal:  Annu Rev Physiol       Date:  2002       Impact factor: 19.318

6.  Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation.

Authors:  Cynthia R L Webster; Usha Srinivasulu; Meenakshisundaram Ananthanarayanan; Frederick J Suchy; M Sawkat Anwer
Journal:  J Biol Chem       Date:  2002-05-28       Impact factor: 5.157

7.  Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp.

Authors:  C R Webster; M S Anwer
Journal:  Am J Physiol       Date:  1999-12

Review 8.  Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters.

Authors:  M Sawkat Anwer; Bruno Stieger
Journal:  Pflugers Arch       Date:  2013-10-03       Impact factor: 3.657

Review 9.  Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions.

Authors:  Takaaki Hirai; Kazuhiro Chida
Journal:  J Biochem       Date:  2003-01       Impact factor: 3.387

10.  Microtubule and motor-dependent endocytic vesicle sorting in vitro.

Authors:  E Bananis; J W Murray; R J Stockert; P Satir; A W Wolkoff
Journal:  J Cell Biol       Date:  2000-10-02       Impact factor: 10.539
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  3 in total

1.  Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane.

Authors:  Pijun Wang; Wen-Jun Wang; Jo Choi-Nurvitadhi; Yaniuska Lescaille; John W Murray; Allan W Wolkoff
Journal:  Hepatology       Date:  2019-06-26       Impact factor: 17.425

2.  Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization.

Authors:  Masashi Iwamoto; Wakana Saso; Ryuichi Sugiyama; Koji Ishii; Mio Ohki; Shushi Nagamori; Ryosuke Suzuki; Hideki Aizaki; Akihide Ryo; Ji-Hye Yun; Sam-Yong Park; Naoko Ohtani; Masamichi Muramatsu; Shingo Iwami; Yasuhito Tanaka; Camille Sureau; Takaji Wakita; Koichi Watashi
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-05       Impact factor: 11.205

3.  Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors.

Authors:  Chitra Saran; Louise Sundqvist; Henry Ho; Jonna Niskanen; Paavo Honkakoski; Kim L R Brouwer
Journal:  J Pharmacol Exp Ther       Date:  2021-11-18       Impact factor: 4.402
  3 in total

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