Valentina Niccolai1, Hanneke van Dijk1, Stephanie Franzkowiak1, Jennifer Finis1, Martin Südmeyer1, Melanie Jonas2, Götz Thomalla3, Hartwig Roman Siebner4,5, Kirsten Müller-Vahl6, Alexander Münchau7, Alfons Schnitzler1, Katja Biermann-Ruben1. 1. Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany. 2. Department of Psychology, Hamburg University, Hamburg, Germany. 3. Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. 4. Danish Research Center for Magnetic Resonance, Copenhagen University Hospital, Copenhagen, Denmark. 5. Department of Neurology, Copenhagen University Hospital Bispebjerg. 6. Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany. 7. Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, University of Lübeck.
Abstract
BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome. METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography. RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity. CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity.
BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome. METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography. RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity. CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity.
Authors: Alonso Zea Vera; Ernest V Pedapati; Travis R Larsh; Kevin Kohmescher; Makoto Miyakoshi; David A Huddleston; Hannah S Jackson; Donald L Gilbert; Paul S Horn; Steve W Wu Journal: Brain Sci Date: 2022-01-24