Literature DB >> 266473

Degradation of [3H]thymidine by a pentosyltransferase (EC 2.4.2.4) in the plasma of man and different animals.

J L Pauly, M G Schuller, A A Zelcer, M J Germain.   

Abstract

[3H]Thymidine is degraded by an enzyme (thymidine phosphorylase; EC 2.4.2.4) which we have identified in the plasma of man and some animals. The presence of this enzyme in plasma or sera used to supplement culture media may, under certain experimental conditions, limit the validity of measuring the uptake of radiolabeled thymidine as a means of defining DNA synthesis.

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Year:  1977        PMID： 266473     DOI： 10.1007/bf01946565

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  THYMIDINE CATABOLISM BY NORMAL AND LEUKEMIC HUMAN LEUKOCYTES.

Authors:  J C MARSH; S PERRY
Journal:  J Clin Invest       Date:  1964-02       Impact factor: 14.808

2.  DEOXYRIBOSYL TRANSFER. I. THYMIDINE PHOSPHORYLASE AND NUCLEOSIDE DEOXYRIBOSYLTRANSFERASE IN NORMAL AND MALIGNANT TISSUES.

Authors:  M ZIMMERMAN; J SEIDENBERG
Journal:  J Biol Chem       Date:  1964-08       Impact factor: 5.157

3.  UPTAKE OF TRITITATED THYMIDINE BY LEUKEMIC CELLS: EFFECT OF VARIOUS LEUKOCYTE PREPARATIONS.

Authors:  S PERRY; J C MARSH
Journal:  Proc Soc Exp Biol Med       Date:  1964-01

4.  The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue.

Authors:  M FRIEDKIN; D ROBERTS
Journal:  J Biol Chem       Date:  1954-03       Impact factor: 5.157

5.  Pyrimidine nucleoside phosphorylases of rat liver. Separation by ion exchange chromatography and studies of the effect of cytidine or uridine administration.

Authors:  E W Yamada
Journal:  J Biol Chem       Date:  1968-04-10       Impact factor: 5.157

6.  Pentosyl transfer mechanisms of the mammalian nucleoside phosphorylases.

Authors:  T A Krenitsky
Journal:  J Biol Chem       Date:  1968-06-10       Impact factor: 5.157

7.  Purification of thymidine phosphorylase from Escherichia coli and its photoinactivation in the presence of thymine, thymidine, and some halogenated analogs.

Authors:  P Voytek
Journal:  J Biol Chem       Date:  1975-05-25       Impact factor: 5.157

8.  The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes. I. Substrate inhibition by thymine and activation by phosphate or arsenate.

Authors:  R C Gallo; S Perry; T R Breitman
Journal:  J Biol Chem       Date:  1967-11-10       Impact factor: 5.157

9.  Elaboration of pyrimidine-specific nucleosidases by human lymphoblastoid cells of established cultures.

Authors:  J L Pauly
Journal:  Cancer Res       Date:  1976-08       Impact factor: 12.701

10.  THE INCORPORATION AND DEGRADATION OF PYRIMIDINE DNA PRECURSORS BY HUMAN LEUCOCYTES.

Authors:  E H COOPER; J D MILTON
Journal:  Br J Cancer       Date:  1964-12       Impact factor: 7.640
  10 in total
  2 in total

1.  Molecular imaging in animal models of disease--every little detail counts!

Authors:  Farrokh Pakzad; Peter J Ell; Ignasi Carrió
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-08       Impact factor: 9.236

2.  Metabolic breakdown of [3H]thymidine and the inability to measure human lymphocyte proliferation by incorporation of radioactivity.

Authors:  J Bodycote; S Wolff
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205
  2 in total

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