Caroline Dissaux1, Frédéric Bodin2, Bruno Grollemund2, Thomas Bridonneau2, Isabelle Kauffmann3, Jean-François Mattern4, Catherine Bruant-Rodier2. 1. Cleft Competence Center, Maxillofacial and Plastic Surgery Department (Head: Catherine Bruant-Rodier, MD, PHD), Strasbourg University Hospital, 1 place de l'Hôpital, 67091 Strasbourg, France. Electronic address: carodissaux@gmail.com. 2. Cleft Competence Center, Maxillofacial and Plastic Surgery Department (Head: Catherine Bruant-Rodier, MD, PHD), Strasbourg University Hospital, 1 place de l'Hôpital, 67091 Strasbourg, France. 3. Cleft Competence Center, Maxillofacial and Plastic Surgery Department (Head: Catherine Bruant-Rodier, MD, PHD), Strasbourg University Hospital, 1 place de l'Hôpital, 67091 Strasbourg, France; Pediatric Surgery Department, Strasbourg University Hospital, Hôpital de Hautepierre, Avenue Molière, 67200 Strasbourg, France. 4. Imaging Department, CBCT Department, Strasbourg University Hospital, Hôpital de Hautepierre, Avenue Molière, 67200 Strasbourg, France; Cabinet de radiologie et d'imagerie médicale de Bischwiller, 13 rue Poincaré, 67240 Bischwiller, France.
Abstract
BACKGROUND AND PURPOSE: Although alveolar cleft bone grafting is the most widely accepted approach, controversies remain on the operative timing. METHODS: A consecutive retrospective series of 28 patients who received alveolar bone grafting was examined and divided into 2 groups depending on the age at the time of bone graft. Group A (14 patients) was operated at a mean age of 5.2 years [range, 4-7] and Group B (14 patients) at a mean age of 10 years [range, 8.5-13]. All the children were assessed clinically and by Cone Beam Computed Tomography (CBCT) before bone grafting and 6 months post-operatively. Cleft and bone graft dimensions, volumes were assessed using Osirix v.3.9.2. Residual bone graft coefficient (Bone Graft Volume on 6-months Postoperative CBCT/Alveolar Cleft Volume) was calculated. Complications, tooth movement or dental agenesis were also reported. RESULTS: The sample was uniform within both groups, considering cleft forms, pre-surgical fistula rate and cleft volume. Residual bone graft coefficient reached 63.3% in Group A and 46.2% in Group B (p = 0.012). Results of residual bone graft are also influenced by tooth eruption through the graft (p = 0.007 in Group A and p = 0.02 in Group B). CONCLUSIONS: This 3D analysis highlighted higher success of alveolar bone grafts when children are operated earlier around 5 years. LEVEL OF EVIDENCE: Therapeutic study. Level III/retrospective comparative study.
BACKGROUND AND PURPOSE: Although alveolar cleft bone grafting is the most widely accepted approach, controversies remain on the operative timing. METHODS: A consecutive retrospective series of 28 patients who received alveolar bone grafting was examined and divided into 2 groups depending on the age at the time of bone graft. Group A (14 patients) was operated at a mean age of 5.2 years [range, 4-7] and Group B (14 patients) at a mean age of 10 years [range, 8.5-13]. All the children were assessed clinically and by Cone Beam Computed Tomography (CBCT) before bone grafting and 6 months post-operatively. Cleft and bone graft dimensions, volumes were assessed using Osirix v.3.9.2. Residual bone graft coefficient (Bone Graft Volume on 6-months Postoperative CBCT/Alveolar Cleft Volume) was calculated. Complications, tooth movement or dental agenesis were also reported. RESULTS: The sample was uniform within both groups, considering cleft forms, pre-surgical fistula rate and cleft volume. Residual bone graft coefficient reached 63.3% in Group A and 46.2% in Group B (p = 0.012). Results of residual bone graft are also influenced by tooth eruption through the graft (p = 0.007 in Group A and p = 0.02 in Group B). CONCLUSIONS: This 3D analysis highlighted higher success of alveolar bone grafts when children are operated earlier around 5 years. LEVEL OF EVIDENCE: Therapeutic study. Level III/retrospective comparative study.
Authors: Lisa Friedlander; Rémy Choquet; Eva Galliani; Myriam de Chalendar; Claude Messiaen; Amélie Ruel; Marie-Paule Vazquez; Ariane Berdal; Corinne Alberti; Muriel De La Dure Molla Journal: Orphanet J Rare Dis Date: 2017-05-19 Impact factor: 4.123
Authors: Stephan Christian Möhlhenrich; Kristian Kniha; Zuzanna Magnuska; Felix Gremse; Florian Peters; Gholamreza Danesh; Frank Hölzle; Ali Modabber Journal: Sci Rep Date: 2020-11-26 Impact factor: 4.379