Literature DB >> 26646496

Can aging be 'drugged'?

Celine E Riera1,2,3, Andrew Dillin1,2,3.   

Abstract

The engines that drive the complex process of aging are being identified by model-organism research, thereby providing potential targets and rationale for drug studies. Several studies of small molecules have already been completed in animal models with the hope of finding an elixir for aging, with a few compounds showing early promise. What lessons can we learn from drugs currently being tested, and which pitfalls can we avoid in our search for a therapeutic for aging? Finally, we must also ask whether an elixir for aging would be applicable to everyone, or whether we age differently, thus potentially shortening lifespan in some individuals.

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Year:  2015        PMID: 26646496     DOI: 10.1038/nm.4005

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


  14 in total

Review 1.  The role of epigenetics in renal ageing.

Authors:  Paul G Shiels; Dagmara McGuinness; Maria Eriksson; Jeroen P Kooman; Peter Stenvinkel
Journal:  Nat Rev Nephrol       Date:  2017-06-19       Impact factor: 28.314

2.  miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.

Authors:  Huachun Cui; Jing Ge; Na Xie; Sami Banerjee; Yong Zhou; Rui-Ming Liu; Victor J Thannickal; Gang Liu
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2016-12-15       Impact factor: 5.464

3.  Novel Contributors and Mechanisms of Cellular Senescence in Hypertension-Associated Premature Vascular Aging.

Authors:  Cameron G McCarthy; Camilla F Wenceslau; R Clinton Webb; Bina Joe
Journal:  Am J Hypertens       Date:  2019-07-17       Impact factor: 2.689

4.  The Effect of Low-Dose Aspirin on Frailty Phenotype and Frailty Index in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly Study.

Authors:  Sara E Espinoza; Robyn L Woods; A R M Saifuddin Ekram; Michael E Ernst; Galina Polekhina; Rory Wolfe; Raj C Shah; Stephanie A Ward; Elsdon Storey; Mark R Nelson; Christopher M Reid; Jessica E Lockery; Suzanne G Orchard; Ruth Trevaks; Sharyn M Fitzgerald; Nigel P Stocks; Andy Chan; John J McNeil; Anne M Murray; Anne B Newman; Joanne Ryan
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2022-10-06       Impact factor: 6.591

Review 5.  Temporal Control of Axonal Transport: The Extreme Case of Organismal Ageing.

Authors:  Francesca Mattedi; Alessio Vagnoni
Journal:  Front Cell Neurosci       Date:  2019-08-23       Impact factor: 5.505

6.  Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.

Authors:  Jorge Iván Castillo-Quan; Li Li; Kerri J Kinghorn; Dobril K Ivanov; Luke S Tain; Cathy Slack; Fiona Kerr; Tobias Nespital; Janet Thornton; John Hardy; Ivana Bjedov; Linda Partridge
Journal:  Cell Rep       Date:  2016-04-07       Impact factor: 9.423

7.  Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium.

Authors:  Preety Bajwa; Prathima B Nagendra; Sarah Nielsen; Subhransu S Sahoo; Amanda Bielanowicz; Janine M Lombard; J Erby Wilkinson; Richard A Miller; Pradeep S Tanwar
Journal:  Oncotarget       Date:  2016-04-12

8.  A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Aging Drosophila Neurons.

Authors:  Alessio Vagnoni; Simon L Bullock
Journal:  Curr Biol       Date:  2018-03-29       Impact factor: 10.834

9.  Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease.

Authors:  Charvi Syal; Jayasankar Kosaraju; Laura Hamilton; Anne Aumont; Alphonse Chu; Sailendra Nath Sarma; Jacob Thomas; Matthew Seegobin; F Jeffrey Dilworth; Ling He; Fredric E Wondisford; Robert Zimmermann; Martin Parent; Karl Fernandes; Jing Wang
Journal:  Theranostics       Date:  2020-05-15       Impact factor: 11.556

10.  Metformin reverses established lung fibrosis in a bleomycin model.

Authors:  Sunad Rangarajan; Nathaniel B Bone; Anna A Zmijewska; Shaoning Jiang; Dae Won Park; Karen Bernard; Morgan L Locy; Saranya Ravi; Jessy Deshane; Roslyn B Mannon; Edward Abraham; Victor Darley-Usmar; Victor J Thannickal; Jaroslaw W Zmijewski
Journal:  Nat Med       Date:  2018-07-02       Impact factor: 53.440

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