Peter Sieljacks1, Andreas Matzon1, Mathias Wernbom2,3, Steffen Ringgaard4, Kristian Vissing1, Kristian Overgaard5. 1. Section of Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Århus, Denmark. 2. Department of Food and Nutrition and Sport Science, Center for Health and Performance, University of Gothenburg, Göteborg, Sweden. 3. Lundberg Laboratory for Orthopaedic Research, Department of Orthopedics, The Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden. 4. Department of Clinical Medicine, MR-Research Centre, Aarhus University Hospital, Århus, Denmark. 5. Section of Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Århus, Denmark. ko@idraet.au.dk.
Abstract
PURPOSE:Blood-flow restricted resistance exercise training (BFRE) is suggested to be effective in rehabilitation training, but more knowledge is required about its potential muscle damaging effects. Therefore, we investigated muscle-damaging effects of BFRE performed to failure and possible protective effects of previous bouts of BFRE or maximal eccentric exercise (ECC). METHODS:Seventeen healthy young men were allocated into two groups completing two exercise bouts separated by 14 days. One group performed BFRE in both exercise bouts (BB). The other group performed ECC in the first and BFRE in the second bout. BFRE was performed to failure. Indicators of muscle damage were evaluated before and after exercise. RESULTS: The first bout in the BB group led to decrements in maximum isometric torque, and increases in muscle soreness, muscle water retention, and serum muscle protein concentrations after exercise. These changes were comparable in magnitude and time course to what was observed after first bout ECC. An attenuated response was observed in the repeated exercise bout in both groups. CONCLUSION: We conclude that unaccustomed single-bout BFRE performed to failure induces significant muscle damage. Additionally, both ECC and BFRE can precondition against muscle damage induced by a subsequent bout of BFRE.
RCT Entities:
PURPOSE: Blood-flow restricted resistance exercise training (BFRE) is suggested to be effective in rehabilitation training, but more knowledge is required about its potential muscle damaging effects. Therefore, we investigated muscle-damaging effects of BFRE performed to failure and possible protective effects of previous bouts of BFRE or maximal eccentric exercise (ECC). METHODS: Seventeen healthy young men were allocated into two groups completing two exercise bouts separated by 14 days. One group performed BFRE in both exercise bouts (BB). The other group performed ECC in the first and BFRE in the second bout. BFRE was performed to failure. Indicators of muscle damage were evaluated before and after exercise. RESULTS: The first bout in the BB group led to decrements in maximum isometric torque, and increases in muscle soreness, muscle water retention, and serum muscle protein concentrations after exercise. These changes were comparable in magnitude and time course to what was observed after first bout ECC. An attenuated response was observed in the repeated exercise bout in both groups. CONCLUSION: We conclude that unaccustomed single-bout BFRE performed to failure induces significant muscle damage. Additionally, both ECC and BFRE can precondition against muscle damage induced by a subsequent bout of BFRE.
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