Literature DB >> 26645321

A mild hydration of nitriles catalysed by copper(ii) acetate.

Patricia Marcé1, James Lynch1, A John Blacker2, Jonathan M J Williams1.   

Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Entities:  

Year:  2016        PMID： 26645321     DOI： 10.1039/c5cc08714g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  DIPEA-induced activation of OH- for the synthesis of amides via photocatalysis.

Authors:  Mei Wu; Sheng Huang; Huiqing Hou; Jie Lin; Mei Lin; Sunying Zhou; Zhiqiang Zheng; Weiming Sun; Fang Ke
Journal:  RSC Adv       Date:  2022-05-16       Impact factor: 4.036

2.  Cu(OTf)2 -Mediated Cross-Coupling of Nitriles and N-Heterocycles with Arylboronic Acids to Generate Nitrilium and Pyridinium Products*.

Authors:  Nicola L Bell; Chao Xu; James W B Fyfe; Julien C Vantourout; Jeremy Brals; Sonia Chabbra; Bela E Bode; David B Cordes; Alexandra M Z Slawin; Thomas M McGuire; Allan J B Watson
Journal:  Angew Chem Int Ed Engl       Date:  2021-02-26       Impact factor: 15.336

3.  Process Development of the Copper(II)-Catalyzed Dehydration of a Chiral Aldoxime and Rational Selection of the Co-Substrate.

Authors:  Jannis Nonnhoff; Harald Gröger
Journal:  ChemistryOpen       Date:  2021-12-10       Impact factor: 2.630

4.  Annulation cascade of arylnitriles with alkynes to stable delocalized PAH carbocations via intramolecular rhodium migration.

Authors:  Jiangliang Yin; Fulin Zhou; Lei Zhu; Mufan Yang; Yu Lan; Jingsong You
Journal:  Chem Sci       Date:  2018-05-29       Impact factor: 9.825

5.  Assembly of 1H-isoindole derivatives by selective carbon-nitrogen triple bond activation: access to aggregation-induced emission fluorophores for lipid droplet imaging.

Authors:  Dandan He; Zeyan Zhuang; Xu Wang; Jiawei Li; Jianxiao Li; Wanqing Wu; Zujin Zhao; Huanfeng Jiang; Ben Zhong Tang
Journal:  Chem Sci       Date:  2019-06-12       Impact factor: 9.825

6.  Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA.

Authors:  Yajun Sun; Weiwei Jin; Chenjiang Liu
Journal:  Molecules       Date:  2019-10-24       Impact factor: 4.411
  6 in total

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