Literature DB >> 2664530

[Synthesis and biochemical actions of idebenone and related compounds. Ubiquinone and related compounds, XL].

H Morimoto1.   

Abstract

Syntheses of some metabolites of ubiquinone and of related compounds are described. Idebenone (QSA-10), a methyl-dimethoxy-benzoquinone bearing an omega-hydroxydecyl side chain in 3-position, restored the oxidation of succinate and of NADH in ubiquinone-depleted mitochondrial preparations and showed a stabilizing effect on lysosomal membranes and an inhibitory effect on cAMP-phosphodiesterase. It inhibited lipid peroxidation in canine brain mitochondria and in microsomes from canine brain and rat liver. Administered orally to rats, it increased the respiratory control index for glutamate and succinate oxidation but had no effect on the ADP/O2 ratio. Pharmacological effects of idebenon are also briefly discussed.

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Year:  1989        PMID： 2664530     DOI： 10.1007/bf00627686

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN： 0028-1042


  13 in total

1.  Studies on the electron-transport system. 27. The respiratory activity of acetoneextracted beef-heart mitochondria: role of coenzyme Q and other lipids.

Authors:  R L LESTER; S FLEISCHER
Journal:  Biochim Biophys Acta       Date:  1961-02-18

2.  Metabolism of ubiquinone-7.

Authors:  I Imada; M Watanabe; N Matsumoto; H Morimoto
Journal:  Biochemistry       Date:  1970-07-07       Impact factor: 3.162

3.  Synthesis of ubiquinone-7 metabolites.

Authors:  M Watanabe; I Imada; H Morimoto
Journal:  Biochemistry       Date:  1970-07-07       Impact factor: 3.162

4.  Effects of 6-(omega-substituted alkyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinones and related compounds on mitochondrial succinate and reduced nicotinamide adenine dinucleotide oxidase systems.

Authors:  K Okamoto; M Matsumoto; M Watanabe; M Kawada; T Imamoto; I Imada
Journal:  Chem Pharm Bull (Tokyo)       Date:  1985-09       Impact factor: 1.645

5.  Synthesis of quinones having carboxy- and hydroxy-alkyl side chains, and their effects on rat-liver lysosomal membrane.

Authors:  K Okamoto; M Watanabe; M Kawada; G Goto; Y Ashida; K Oda; A Yajima; I Imada; H Morimoto
Journal:  Chem Pharm Bull (Tokyo)       Date:  1982-08       Impact factor: 1.645

6.  Ubiquinone and related compounds. 28. Effect of the metabolites of alpha-tocopherol, phylloquinone and ubiquinone on the stability of rat-liver lysosomal membrane.

Authors:  M Watanabe; R Negishi; I Imada; M Nishikawa; H Morimoto
Journal:  Chem Pharm Bull (Tokyo)       Date:  1974-01       Impact factor: 1.645

7.  Synthesis, metabolism, and in vitro biological activities of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (CV-2619)-related compounds.

Authors:  K Okamoto; M Watanabe; H Morimoto; I Imada
Journal:  Chem Pharm Bull (Tokyo)       Date:  1988-01       Impact factor: 1.645

8.  Effects of Q metabolites and related compounds on mitochondrial succinate and NADH oxidase systems.

Authors:  K Okamoto; M Kawada; M Watanabe; S Kobayashi; I Imada; H Morimoto
Journal:  Biochim Biophys Acta       Date:  1982-10-18

9.  Stimulation of the respiratory and phosphorylating activities in rat brain mitochondria by idebenone (CV-2619), a new agent improving cerebral metabolism.

Authors:  Y Sugiyama; T Fujita
Journal:  FEBS Lett       Date:  1985-05-06       Impact factor: 4.124

10.  Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs.

Authors:  Y Sugiyama; T Fujita; M Matsumoto; K Okamoto; I Imada
Journal:  J Pharmacobiodyn       Date:  1985-12
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