Literature DB >> 26645050

The Emerging Role of ABL Kinases in Solid Tumors.

Jun Wang1, Ann Marie Pendergast1.   

Abstract

The Abelson (ABL) tyrosine kinases were identified as drivers of leukemia in mice and humans. Emerging data has shown a role for the ABL family kinases, ABL1 and ABL2, in the progression of several solid tumors. This review will focus on recent reports of the involvement of the ABL kinases in tumor progression using mouse models as well as recent data generated from genomic and proteomic studies linking enhanced expression and hyper-activation of the ABL kinases to some human cancers. Preclinical studies on small molecule inhibitors of the ABL kinases suggest that their use may have beneficial effects for the treatment of selected solid tumors.

Entities:  

Keywords:  ABL; cancer; leukemia; metabolism; metastasis; therapy resistance

Year:  2015        PMID： 26645050      PMCID： PMC4669955          DOI： 10.1016/j.trecan.2015.07.004

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  83 in total

1.  Inhibition of c-ABL sensitizes breast cancer cells to the dual ErbB receptor tyrosine kinase inhibitor lapatinib (GW572016).

Authors:  Yuan-Hung Lo; Po-Chun Ho; Huajun Zhao; Shao-Chun Wang
Journal:  Anticancer Res       Date:  2011-03       Impact factor: 2.480

2.  Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.

Authors:  Tea Pemovska; Eric Johnson; Mika Kontro; Gretchen A Repasky; Jeffrey Chen; Peter Wells; Ciarán N Cronin; Michele McTigue; Olli Kallioniemi; Kimmo Porkka; Brion W Murray; Krister Wennerberg
Journal:  Nature       Date:  2015-02-09       Impact factor: 49.962

3.  Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO.

Authors:  Masahiro Sonoshita; Yoshiro Itatani; Fumihiko Kakizaki; Kenji Sakimura; Toshio Terashima; Yu Katsuyama; Yoshiharu Sakai; M Mark Taketo
Journal:  Cancer Discov       Date:  2014-11-28       Impact factor: 39.397

Review 4.  Chronic myeloid leukemia: advances in understanding disease biology and mechanisms of resistance to tyrosine kinase inhibitors.

Authors:  Christopher A Eide; Thomas O'Hare
Journal:  Curr Hematol Malig Rep       Date:  2015-06       Impact factor: 3.952

5.  c-Abl tyrosine kinase regulates cardiac growth and development.

Authors:  Zhaozhu Qiu; Yong Cang; Stephen P Goff
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-28       Impact factor: 11.205

6.  Essential roles for the Abl and Arg tyrosine kinases in neurulation.

Authors:  A J Koleske; A M Gifford; M L Scott; M Nee; R T Bronson; K A Miczek; D Baltimore
Journal:  Neuron       Date:  1998-12       Impact factor: 17.173

Review 7.  Structure and dynamic regulation of Abl kinases.

Authors:  Shoghag Panjarian; Roxana E Iacob; Shugui Chen; John R Engen; Thomas E Smithgall
Journal:  J Biol Chem       Date:  2013-01-11       Impact factor: 5.157

8.  A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.

Authors:  Rina Plattner; Brenda J Irvin; Shuling Guo; Kevin Blackburn; Andrius Kazlauskas; Robert T Abraham; John D York; Ann Marie Pendergast
Journal:  Nat Cell Biol       Date:  2003-04       Impact factor: 28.824

9.  Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.

Authors:  James S Duncan; Martin C Whittle; Kazuhiro Nakamura; Amy N Abell; Alicia A Midland; Jon S Zawistowski; Nancy L Johnson; Deborah A Granger; Nicole Vincent Jordan; David B Darr; Jerry Usary; Pei-Fen Kuan; David M Smalley; Ben Major; Xiaping He; Katherine A Hoadley; Bing Zhou; Norman E Sharpless; Charles M Perou; William Y Kim; Shawn M Gomez; Xin Chen; Jian Jin; Stephen V Frye; H Shelton Earp; Lee M Graves; Gary L Johnson
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

10.  c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.

Authors:  Leann S Fiore; Sourik S Ganguly; James Sledziona; Michael L Cibull; Chi Wang; Dana L Richards; Janna M Neltner; Carol Beach; Joseph R McCorkle; David M Kaetzel; Rina Plattner
Journal:  Oncogene       Date:  2013-10-07       Impact factor: 9.867
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  29 in total

Review 1.  Allosteric Inhibition of ABL Kinases: Therapeutic Potential in Cancer.

Authors:  Jill K Jones; Eric M Thompson
Journal:  Mol Cancer Ther       Date:  2020-06-30       Impact factor: 6.261

2.  p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance.

Authors:  Dannah R Miller; Matthew A Ingersoll; Arpita Chatterjee; Brian Baker; Shashank Shrishrimal; Elizabeth A Kosmacek; Yuxiang Zhu; Pi-Wan Cheng; Rebecca E Oberley-Deegan; Ming-Fong Lin
Journal:  Free Radic Biol Med       Date:  2019-05-14       Impact factor: 7.376

3.  Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis.

Authors:  Jing Jin Gu; Clay Rouse; Xia Xu; Jun Wang; Mark W Onaitis; Ann Marie Pendergast
Journal:  JCI Insight       Date:  2016-12-22

4.  EnABLing Tumor Growth and Progression: Recent progress in unraveling the functions of ABL kinases in solid tumor cells.

Authors:  Rakshamani Tripathi; Zulong Liu; Rina Plattner
Journal:  Curr Pharmacol Rep       Date:  2018-07-23

5.  Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.

Authors:  Christopher M Coleman; Jeanne M Sisk; Rebecca M Mingo; Elizabeth A Nelson; Judith M White; Matthew B Frieman
Journal:  J Virol       Date:  2016-09-12       Impact factor: 5.103

6.  High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer.

Authors:  Yun Liu; Chen Shao; Linqi Zhu; Sihong Jiang; Guanlin Li; Wei Zhang; Yajing Lin; Ying Ni; Hui Cao; Shihe Shao
Journal:  Dig Dis Sci       Date:  2018-05-16       Impact factor: 3.199

Review 7.  Recurrent Fusion of the GRB2 Associated Binding Protein 1 (GAB1) Gene With ABL Proto-oncogene 1 (ABL1) in Benign Pediatric Soft Tissue Tumors.

Authors:  Ioannis Panagopoulos; Ludmila Gorunova; Kristin Andersen; Svetlana Tafjord; Marius Lund-Iversen; Ingvild Lobmaier; Francesca Micci; Sverre Heim
Journal:  Cancer Genomics Proteomics       Date:  2020 Sep-Oct       Impact factor: 4.069

8.  ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.

Authors:  Jun Wang; Clay Rouse; Jeff S Jasper; Ann Marie Pendergast
Journal:  Sci Signal       Date:  2016-02-02       Impact factor: 8.192

9.  Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.

Authors:  Rakshamani Tripathi; Leann S Fiore; Dana L Richards; Yuchen Yang; Jinpeng Liu; Chi Wang; Rina Plattner
Journal:  Sci Signal       Date:  2018-02-20       Impact factor: 8.192

Review 10.  Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade.

Authors:  Jillian Hattaway Luttman; Ashley Colemon; Benjamin Mayro; Ann Marie Pendergast
Journal:  Cell Commun Signal       Date:  2021-05-22       Impact factor: 7.525
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