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Literature DB >> 2664491

Mutagens as carcinogens: development of current concepts.

Abstract

The earliest work on reactions of mutagenic carcinogens with DNA, in which the author participated, is recalled in a personal reminiscence. Some significant consequences of this approach for studies of the mode of action of mutagenic carcinogens are briefly discussed, with regard to the types of mutation induced, and to current concepts of the involvement of somatic mutation in experimental cancer and in the aetiology of human cancer.

Entities: Disease Species

Mesh：

Substances：
Carcinogens
Mutagens
DNA

Year: 1989 PMID： 2664491 DOI： 10.1016/0027-5107(89)90028-6

Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433

Keyword Cloud
Cited

11 in total

1. Frequent mutation of the p53 gene in human esophageal cancer.

Authors: M C Hollstein; R A Metcalf; J A Welsh; R Montesano; C C Harris
Journal: Proc Natl Acad Sci U S A Date: 1990-12 Impact factor: 11.205

2. RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana.

Authors: Anja Mannuss; Stefanie Dukowic-Schulze; Stefanie Suer; Frank Hartung; Michael Pacher; Holger Puchta
Journal: Plant Cell Date: 2010-10-22 Impact factor: 11.277

3. Germline selection: population genetic aspects of the sexual/asexual life cycle.

Authors: I M Hastings
Journal: Genetics Date: 1991-12 Impact factor: 4.562

4. A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.

Authors: Michael Chang; Mohammed Bellaoui; Charles Boone; Grant W Brown
Journal: Proc Natl Acad Sci U S A Date: 2002-12-13 Impact factor: 11.205

5. Effect of N7-methylation on base pairing patterns of guanine: a DFT study.

Authors: Swarnadeep Biswas; Pradeep Kumar Shukla
Journal: J Mol Model Date: 2021-05-25 Impact factor: 1.810

6. Specificity of base substitutions induced by the acridine mutagen ICR-191: mispairing by guanine N7 adducts as a mutagenic mechanism.

Authors: S R Sahasrabudhe; X Luo; M Z Humayun
Journal: Genetics Date: 1991-12 Impact factor: 4.562

Mutagens as carcinogens: development of current concepts.

1. Frequent mutation of the p53 gene in human esophageal cancer.

2. RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana.

3. Germline selection: population genetic aspects of the sexual/asexual life cycle.

4. A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.

5. Effect of N7-methylation on base pairing patterns of guanine: a DFT study.

6. Specificity of base substitutions induced by the acridine mutagen ICR-191: mispairing by guanine N7 adducts as a mutagenic mechanism.

7. Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.

8. Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.

9. Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression.

10. Leveraging DNA damage response signaling to identify yeast genes controlling genome stability.