Rasoul Mohammadi1, Mohsen Meidani2, Kamyar Mostafavizadeh2, Bijan Iraj3, Pooria Hamedani3, Sayed Mohammad Amin Sayedain4, Mojgan Mokhtari5. 1. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Department of Infectious Diseases, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Department of Endocrinology, Isfahan University of Medical Sciences, Isfahan, Iran. 4. Department of Cardiology, Chamran Hospital (Heart Center), Isfahan University of Medical Sciences, Isfahan, Iran. 5. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
BACKGROUND: Rhinocerebral mucormycosis is a fatal infection typically affecting diabetic or immunosuppressed patients. In most cases, infection is caused by inhalation of fungal spores. Mortality rate of patients is very high (40-85%). CASE PRESENTATION: In this study, three diabetic patients with rhinocerebral mucormycosis were presented. The etiologic agents of mucormycosis in two patients were isolated and identified by sequence analysis and data were registered in Gene bank database. CONCLUSION: In patients with mucoreosis, early detection, surgical excision and appropriate debridement, suitable antifungal therapy, and control of risk factors like diabetes mellitus are the main parameters of successful management of this lethal infection.
BACKGROUND:Rhinocerebral mucormycosis is a fatal infection typically affecting diabetic or immunosuppressed patients. In most cases, infection is caused by inhalation of fungal spores. Mortality rate of patients is very high (40-85%). CASE PRESENTATION: In this study, three diabeticpatients with rhinocerebral mucormycosis were presented. The etiologic agents of mucormycosis in two patients were isolated and identified by sequence analysis and data were registered in Gene bank database. CONCLUSION: In patients with mucoreosis, early detection, surgical excision and appropriate debridement, suitable antifungal therapy, and control of risk factors like diabetes mellitus are the main parameters of successful management of this lethal infection.
Authors: Amir Hossein Sarrami; Mehrdad Setareh; Masoud Izadinejad; Noushin Afshar-Moghaddam; Mohammad Mehdi Baradaran-Mahdavi; Mohsen Meidani Journal: Int J Prev Med Date: 2013-12