INTRODUCTION: Penile squamous cell carcinoma (SCC) is rare in North America; however, the morbidity can be devastating. This analysis represents the first reported penile cancer experience at a tertiary care centre in Canada. METHODS: We carried out a retrospective review of all patients who received care at our centre for penile SCC from 2005 until the present time. Epidemiological and clinical data were collected for all patients. Survival analysis was performed using Kaplan-Meier methods with log-rank test and Cox regression for univariate and multivariate analysis, respectively. RESULTS: We identified 42 patients who were treated at our centre for penile SCC. Of these, 29% underwent excisional biopsy, 38% had partial penectomy, and 33% had total penectomy. Five patients with high-risk tumours underwent modified inguinal lymph node dissection (ILND), while 7 patients had radical ILND for clinically palpable disease. Overall, the median cancer specific survival (CSS) was undefined, with a 60% survival at 102 months. However CSS was significantly correlated to pT stage, pN stage, and tumour grade. The median follow-up was 25 months (interquartile range: 11-48). CONCLUSION: These findings confirm the poor CSS of patients with positive lymph nodes in penile SCC. Patients with pN0 after ILND had a durable CSS. Risk factors for penile SCC were confirmed as elevated body mass index, positive smoking history, and lack of circumcision. This first epidemiologic report on penile SCC from a Canadian tertiary care centre should be expanded to other national centres.
INTRODUCTION:Penile squamous cell carcinoma (SCC) is rare in North America; however, the morbidity can be devastating. This analysis represents the first reported penile cancer experience at a tertiary care centre in Canada. METHODS: We carried out a retrospective review of all patients who received care at our centre for penile SCC from 2005 until the present time. Epidemiological and clinical data were collected for all patients. Survival analysis was performed using Kaplan-Meier methods with log-rank test and Cox regression for univariate and multivariate analysis, respectively. RESULTS: We identified 42 patients who were treated at our centre for penile SCC. Of these, 29% underwent excisional biopsy, 38% had partial penectomy, and 33% had total penectomy. Five patients with high-risk tumours underwent modified inguinal lymph node dissection (ILND), while 7 patients had radical ILND for clinically palpable disease. Overall, the median cancer specific survival (CSS) was undefined, with a 60% survival at 102 months. However CSS was significantly correlated to pT stage, pN stage, and tumour grade. The median follow-up was 25 months (interquartile range: 11-48). CONCLUSION: These findings confirm the poor CSS of patients with positive lymph nodes in penile SCC. Patients with pN0 after ILND had a durable CSS. Risk factors for penile SCC were confirmed as elevated body mass index, positive smoking history, and lack of circumcision. This first epidemiologic report on penile SCC from a Canadian tertiary care centre should be expanded to other national centres.
Authors: Oliver W Hakenberg; Eva M Compérat; Suks Minhas; Andrea Necchi; Chris Protzel; Nick Watkin Journal: Eur Urol Date: 2014-11-01 Impact factor: 20.096
Authors: Carlos Bermejo; J Erik Busby; Philippe E Spiess; Lior Heller; Lance C Pagliaro; Curtis A Pettaway Journal: J Urol Date: 2007-04 Impact factor: 7.450
Authors: Mariela R Pow-Sang; Ubirajara Ferreira; Julio M Pow-Sang; Aguinaldo C Nardi; Victor Destefano Journal: Urology Date: 2010-08 Impact factor: 2.649
Authors: Lyriane Apolinário de Araújo; Adriano Augusto Peclat De Paula; Hellen da Silva Cintra de Paula; Jessica Enocêncio Porto Ramos; Brunna Rodrigues de Oliveira; Keila Patrícia Almeida De Carvalho; Rafael Alves Guimarães; Rita de Cássia Gonçalves de Alencar; Eliza Carla Barroso Duarte; Silvia Helena Rabelo Santos; Vera Aparecida Saddi; Megmar Aparecida Dos Santos Carneiro Journal: PLoS One Date: 2018-06-27 Impact factor: 3.240