Arno Kornberg1, Ulrike Witt1, Jennifer Kornberg2, Katharina Müller3, Helmut Friess1, Katharina Thrum4. 1. a Department of Surgery, Klinikum Rechts Der Isar, Technical University , Munich , Germany . 2. b Department of Anaesthesiology , Klinikum Großhadern, LMU Munich , Germany . 3. c Department of Surgery, University of Jena , Jena , UK , and. 4. d Institute of Pathology , Helios Klinikum, Berlin , Germany.
Abstract
CONTEXT: C-reactive protein (CRP), a biomarker of inflammation, may correlate with prognosis in several malignancies. OBJECTIVE: To investigate the prognostic impact of early postoperative peak serum levels of CRP on tumor-specific outcome in 106 liver transplant patients with hepatocellular carcinoma (HCC). METHODS AND RESULTS: In multivariate Cox regression analysis, a posttransplant elevated peak CRP level (>versus ≤ 3.5 mg/dl) was identified as an independent predictor of poor recurrence-free survival (p = 0.01; HR = 4.04; CI = 1.399-11.640). CONCLUSION: Early postoperative serum CRP may serve as a useful inflammation-based biomarker of outcome in liver transplant patients with HCC.
CONTEXT: C-reactive protein (CRP), a biomarker of inflammation, may correlate with prognosis in several malignancies. OBJECTIVE: To investigate the prognostic impact of early postoperative peak serum levels of CRP on tumor-specific outcome in 106 liver transplant patients with hepatocellular carcinoma (HCC). METHODS AND RESULTS: In multivariate Cox regression analysis, a posttransplant elevated peak CRP level (>versus ≤ 3.5 mg/dl) was identified as an independent predictor of poor recurrence-free survival (p = 0.01; HR = 4.04; CI = 1.399-11.640). CONCLUSION: Early postoperative serum CRP may serve as a useful inflammation-based biomarker of outcome in liver transplant patients with HCC.
Entities:
Keywords:
Inflammation; Milan criteria; ischemia-reperfusion injury; liver transplantation; tumor recurrence
Authors: E Dudley Colhoun; C Gunnar Forsberg; Kenneth D Chavin; Prabhakar K Baliga; David J Taber Journal: Surgery Date: 2016-10-19 Impact factor: 3.982
Authors: Arno Kornberg; Martina Schernhammer; Jennifer Kornberg; Helmut Friess; Katharina Thrum Journal: Dig Dis Sci Date: 2018-09-27 Impact factor: 3.199