Literature DB >> 26643658

Dermal Adipocytes: From Irrelevance to Metabolic Targets?

Ilja L Kruglikov1, Philipp E Scherer2.   

Abstract

Dermal white adipose tissue (dWAT) has received little appreciation in the past as a distinct entity from the better recognized subcutaneous white adipose tissue (sWAT). However, recent work has established dWAT as an important contributor to a multitude of processes, including immune response, wound healing and scarring, hair follicle (HF) growth, and thermoregulation. Unique metabolic contributions have also been attributed to dWAT, at least in part due to its thermic insulation properties and response to cold exposure. Dermal adipocytes can also undergo an adipocyte-myofibroblast transition (AMT), a process that is suspected to have an important role in several pathophysiological processes within the skin. Here, we discuss emerging concepts regarding dWAT physiology and its significance to a variety of cellular processes.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  adipocyte-myofibroblast transition; adipose derived stem cells; dermal insulation; pigmentation; scarring

Mesh：

Year:  2015        PMID： 26643658      PMCID： PMC4698208          DOI： 10.1016/j.tem.2015.11.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  59 in total

1.  Tracking adipogenesis during white adipose tissue development, expansion and regeneration.

Authors:  Qiong A Wang; Caroline Tao; Rana K Gupta; Philipp E Scherer
Journal:  Nat Med       Date:  2013-09-01       Impact factor: 53.440

2.  Adipose tissue engineering with cells in engineered matrices.

Authors:  Lauren Flynn; Kimberly A Woodhouse
Journal:  Organogenesis       Date:  2008-10       Impact factor: 2.500

3.  Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities.

Authors:  Babak Razani; Terry P Combs; Xiao Bo Wang; Philippe G Frank; David S Park; Robert G Russell; Maomi Li; Baiyu Tang; Linda A Jelicks; Philipp E Scherer; Michael P Lisanti
Journal:  J Biol Chem       Date:  2001-12-05       Impact factor: 5.157

4.  Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model.

Authors:  Karen Mak; Aleem Manji; Corrie Gallant-Behm; Colin Wiebe; David A Hart; Hannu Larjava; Lari Häkkinen
Journal:  J Dermatol Sci       Date:  2009-10-24       Impact factor: 4.563

5.  Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4.

Authors:  Kamila Wojciechowicz; Karl Gledhill; Carrie A Ambler; Craig B Manning; Colin A B Jahoda
Journal:  PLoS One       Date:  2013-03-26       Impact factor: 3.240

Review 6.  Thyroid hormone regulation of metabolism.

Authors:  Rashmi Mullur; Yan-Yun Liu; Gregory A Brent
Journal:  Physiol Rev       Date:  2014-04       Impact factor: 37.312

Review 7.  Adipose tissues and thyroid hormones.

Authors:  Maria-Jesus Obregon
Journal:  Front Physiol       Date:  2014-12-11       Impact factor: 4.566

8.  Comparison between human fetal and adult skin.

Authors:  Neeltje A Coolen; Kelly C W M Schouten; Esther Middelkoop; Magda M W Ulrich
Journal:  Arch Dermatol Res       Date:  2009-08-23       Impact factor: 3.017

9.  Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance.

Authors:  Li Kang; Louise Lantier; Arion Kennedy; Jeffrey S Bonner; Wesley H Mayes; Deanna P Bracy; Louis H Bookbinder; Alyssa H Hasty; Curtis B Thompson; David H Wasserman
Journal:  Diabetes       Date:  2013-01-24       Impact factor: 9.461

10.  Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells.

Authors:  Vivek D Desai; Henry C Hsia; Jean E Schwarzbauer
Journal:  PLoS One       Date:  2014-01-23       Impact factor: 3.240
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  42 in total

Review 1.  Multidisciplinary approaches to stimulate wound healing.

Authors:  Rita Businaro; Mariangela Corsi; Tania Di Raimo; Sergio Marasco; Debra L Laskin; Bruno Salvati; Raffaele Capoano; Serafino Ricci; Camilla Siciliano; Giacomo Frati; Elena De Falco
Journal:  Ann N Y Acad Sci       Date:  2016-07-19       Impact factor: 5.691

Review 2.  The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Authors:  Clair Crewe; Yu Aaron An; Philipp E Scherer
Journal:  J Clin Invest       Date:  2017-01-03       Impact factor: 14.808

3.  Dermal white adipose tissue renewal is regulated by the PDGFA/AKT axis.

Authors:  Giuseppe Cappellano; Christian Ploner
Journal:  Stem Cell Investig       Date:  2017-04-07

Review 4.  The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.

Authors:  Chelsea Hepler; Rana K Gupta
Journal:  Mol Cell Endocrinol       Date:  2016-10-12       Impact factor: 4.102

5.  The complexity of PDGFR signaling: regulation of adipose progenitor maintenance and adipocyte-myofibroblast transition.

Authors:  Christian Dani; Alexander Pfeifer
Journal:  Stem Cell Investig       Date:  2017-04-14

Review 6.  Anatomical, Physiological, and Functional Diversity of Adipose Tissue.

Authors:  Rachel K Zwick; Christian F Guerrero-Juarez; Valerie Horsley; Maksim V Plikus
Journal:  Cell Metab       Date:  2018-01-09       Impact factor: 27.287

Review 7.  The Role of Immature and Mature Adipocytes in Hair Cycling.

Authors:  Ilja L Kruglikov; Zhuzhen Zhang; Philipp E Scherer
Journal:  Trends Endocrinol Metab       Date:  2018-12-14       Impact factor: 12.015

8.  Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice.

Authors:  Zhuzhen Zhang; Mengle Shao; Chelsea Hepler; Zhenzhen Zi; Shangang Zhao; Yu A An; Yi Zhu; Alexandra L Ghaben; May-Yun Wang; Na Li; Toshiharu Onodera; Nolwenn Joffin; Clair Crewe; Qingzhang Zhu; Lavanya Vishvanath; Ashwani Kumar; Chao Xing; Qiong A Wang; Laurent Gautron; Yingfeng Deng; Ruth Gordillo; Ilja Kruglikov; Christine M Kusminski; Rana K Gupta; Philipp E Scherer
Journal:  J Clin Invest       Date:  2019-12-02       Impact factor: 14.808

9.  Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages.

Authors:  Israel Hanukoglu; Vijay R Boggula; Hananya Vaknine; Sachin Sharma; Thomas Kleyman; Aaron Hanukoglu
Journal:  Histochem Cell Biol       Date:  2017-01-27       Impact factor: 4.304

10.  Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Authors:  Yi Zhu; Yong Gao; Caroline Tao; Mengle Shao; Shangang Zhao; Wei Huang; Ting Yao; Joshua A Johnson; Tiemin Liu; Aaron M Cypess; Olga Gupta; William L Holland; Rana K Gupta; David C Spray; Herbert B Tanowitz; Lei Cao; Matthew D Lynes; Yu-Hua Tseng; Joel K Elmquist; Kevin W Williams; Hua V Lin; Philipp E Scherer
Journal:  Cell Metab       Date:  2016-09-13       Impact factor: 27.287
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