Literature DB >> 26643128

Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials.

Pavel S Roshanov1, Brittany B Dennis2.   

Abstract

Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82).
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Acute pancreatitis; DDP4 inhibitors; Gliptins; Incretins; Safety

Mesh：

Substances：

Year:  2015        PMID： 26643128     DOI： 10.1016/j.diabres.2015.10.014

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


  5 in total

Review 1.  Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus.

Authors:  Abd A Tahrani; Anthony H Barnett; Clifford J Bailey
Journal:  Nat Rev Endocrinol       Date:  2016-06-24       Impact factor: 43.330

2.  The Risk of Acute Pancreatitis After Initiation of Dipeptidyl Peptidase 4 Inhibitors: Testing a Hypothesis of Subgroup Differences in Older U.S. Adults.

Authors:  Jin-Liern Hong; John B Buse; Michele Jonsson Funk; Virginia Pate; Til Stürmer
Journal:  Diabetes Care       Date:  2018-04-04       Impact factor: 19.112

3.  Efficacy and Safety of Once-Weekly Semaglutide for the Treatment of Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Authors:  Fang-Hong Shi; Hao Li; Min Cui; Zai-Li Zhang; Zhi-Chun Gu; Xiao-Yan Liu
Journal:  Front Pharmacol       Date:  2018-06-04       Impact factor: 5.810

4.  Liraglutide use and evaluation of pancreatic outcomes in a US commercially insured population.

Authors:  Donnie Funch; Kathleen Mortimer; Najat J Ziyadeh; John D Seeger; Ling Li; Heather Norman; Atheline Major-Pedersen; Heidrun Bosch-Traberg; Helge Gydesen; David D Dore
Journal:  Diabetes Obes Metab       Date:  2019-05-24       Impact factor: 6.577

5.  Dipeptidyl peptidase-4 inhibitors, pancreatic cancer and acute pancreatitis: A meta-analysis with trial sequential analysis.

Authors:  Lana C Pinto; Dimitris V Rados; Sabrina S Barkan; Cristiane B Leitão; Jorge L Gross
Journal:  Sci Rep       Date:  2018-01-15       Impact factor: 4.379
  5 in total

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